Results 21 to 30 of about 3,088,438 (300)

Interleukin-21 and its association with chronic periodontitis.

J Indian Soc Periodontol, 2019
Interleukin-21 (IL-21) is a pleiotropic cytokine, well documented to contribute to the development of Th17 cells which have been shown to play an important role in the pathogenesis of periodontitis. Periodontal disease is a chronic infection of tooth-supporting tissue.This study evaluates the saliva and serum levels of IL-21 in patients with chronic ...
Lokhande RV, Ambekar JG, Bhat KG, Dongre NN.   +3 more
europepmc   +4 more sources

Tfh-cell-derived interleukin 21 sustains effector CD8⁺ T cell responses during chronic viral infection. [PDF]

Immunity, 2022
Zander R, Kasmani MY, Chen Y, Topchyan P, Shen J, Zheng S, Burns R, Ingram J, Cui C, Joshi N, Craft J, Zajac A, Cui W.   +12 more
europepmc   +2 more sources

Interleukin-21 promotes thymopoiesis recovery following hematopoietic stem cell transplantation

Journal of Hematology & Oncology, 2017
Background Impaired T cell reconstitution remains a major deterrent in the field of bone marrow (BM) transplantation (BMT) due to pre-conditioning-induced damages inflicted to the thymi of recipient hosts.
Aurélie Tormo, Fatemeh Khodayarian, Yun Cui, Edouard Al-Chami, Reem Kanjarawi, Beatriz Noé, Huijie Wang, Moutih Rafei   +7 more
doaj   +2 more sources

Probiotic Supplementation Improves Glucose Homeostasis and Modulates Interleukin (IL)-21 and IL-22 Levels in Pediatric Patients with Type 1 Diabetes: A Randomized Placebo-Controlled Trial

Metabolites
Background: Probiotics alter gut microbiota and have beneficial effects on immune homeostasis. The role of probiotics in diabetes has been shown in some studies.
Amira Abdel Moneam Adly, Eman Abdel Rahman Ismail, Mahasen Mohamed Abd-Elgawad, Nouran Yousef Salah   +3 more
doaj   +2 more sources

OR18-05 Interleukin 21 Drives The Development Of Autoimmune Diabetes Mellitus During Immune Checkpoint Inhibitor Cancer Therapy [PDF]

J Endocr Soc, 2023
Jessica Ortega, Lauren N Scott, Sarah Wang, Shile Zhang, Ho-Chung Chen, Nicole Huang, Melissa G. Lechner   +6 more
europepmc   +2 more sources

Peripheral TIGIT+ T Follicular Helper Cells That Produce High Levels of Interleukin-21 via OX40 Represent Disease Activity in IgG4-Related Disease. [PDF]

Front Immunol, 2021
Objectives Multiple studies suggest that interleukin (IL)-21 plays a pivotal role in the differentiation of B cells and activation of cytotoxic T cells and is involved in the pathogenesis of IgG4-related disease (IgG4-RD).
Akiyama M, Suzuki K, Yoshimoto K, Yasuoka H, Kaneko Y, Takeuchi T.   +5 more
europepmc   +2 more sources

Regulation of the germinal center and humoral immunity by interleukin-21. [PDF]

J Exp Med, 2020
Here we review the critical and non-redundant functions of IL-21 in regulating humoral immune responses. We particularly focus on studies in natura—from individuals from inborn errors of immunity that impact on IL-21 production and/or function.
Tangye SG, Ma CS.
europepmc   +2 more sources

Modeling the response to interleukin-21 to inform natural killer cell immunotherapy. [PDF]

Immunol Cell Biol
Nayak I, Biondo R, Stewart WC, Fulton RJ, Möker N, Zhang C, Khakoo SI, Das J.   +7 more
europepmc   +2 more sources

Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis [PDF]

Clinical and Experimental Immunology, 2015
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial fibroblast hyperplasia and bone erosion. Fibroblast‐like synoviocytes (FLS) play a pivotal role in RA pathogenesis through aggressive migration and matrix invasion, and
Rui Xing, Ying Jin, Lin Sun, Li Yang, Chao Li, Zijian Li, Xinran Liu, Jinxia Zhao   +7 more
openalex   +2 more sources

Interleukin-17/Interleukin-21 and Interferon-γ producing T cells specific for β2 Glycoprotein I in atherosclerosis inflammation of systemic lupus erythematosus patients with antiphospholipid syndrome

Haematologica, 2019
Systemic lupus erythematosus is frequently associated with antiphospholipid syndrome. Patients with lupus-antiphospholipid syndrome are characterized by recurrent arterial/venous thrombosis, miscarriages, and persistent presence of autoantibodies against
Marisa Benagiano, María Orietta Borghi, Jacopo Romagnoli, Michael Mähler, Chiara Della Bella, Alessia Grassi, Nagaja Capitani, Giacomo Emmi, Arianna Troilo, Elena Silvestri, Lorenzo Emmi, Heba Alnwaisri, Jacopo Bitetti, Simona Tapinassi, Domenico Prisco, Cosima T. Baldari, Pier Luigi Meroni, Mario Milco D’Elios   +17 more
openalex   +3 more sources