Results 291 to 300 of about 3,531,639 (330)

Interleukin-21 and Cancer Therapy

2009
Interleukin-21 (IL-21) is a pleiotropic cytokine structurally similar to IL-2 and IL-15 but with important distinctions in its biological properties. IL-21 is mainly secreted by activated CD4+ T cells, NKT cells, and follicular T helper (Tfh) cells. The IL-21 receptor is expressed physiologically on lymphoid tissues and peripheral blood mononuclear ...
Davis, Ian D., Skak, Kresten, Hunder, Naomi, Smyth, Mark J., Sivakumar, Pallavur V.   +4 more
openaire   +2 more sources

Role of Interleukin-21 in Inflammation and Allergy

Inflammation & Allergy-Drug Targets, 2007
Interleukin-21 (IL-21) is a newly described cytokine, produced by activated CD4+ T cells. Since the discovery in 2000, IL-21 has been the object of intensive research because of its homology to IL-2, IL-4 and IL-15, and its ability to modulate both innate and adaptive immune responses.
Fina D., FANTINI, MASSIMO CLAUDIO, PALLONE, FRANCESCO, MONTELEONE, GIOVANNI   +3 more
openaire   +5 more sources

Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease

Cytokine & Growth Factor Reviews, 2009
Interleukin-21 (IL-21) is produced mostly by activated CD4+ T cells and controls the differentiation and functional activity of effector T helper cells, counteracts the suppressive effects of regulatory T cells, and stimulates non-immune cells to make inflammatory mediators.
MONTELEONE, GIOVANNI, PALLONE, FRANCESCO, Macdonald, T.   +2 more
openaire   +4 more sources

The association of interleukin-21 polymorphisms with interleukin-21 serum levels and risk of systemic lupus erythematosus

Gene, 2014
Systemic lupus erythematosus (SLE) is one of the common autoimmune diseases, with complex genetic components. Interleukin-21 (IL-21) is the most recently discovered member of the type-I cytokine family, which has a variety of effects on the immune system, including B cell activation, plasma cell differentiation, and immunoglobulin production.
Yan Lan, Bin Luo, Jun-Li Wang, Yuan-Wen Jiang, Ye-Sheng Wei   +4 more
openaire   +2 more sources

Interleukin-21: biology and application to cancer therapy

Expert Opinion on Biological Therapy, 2008
IL-21, a recently described common gamma-chain cytokine, can induce the maturation and enhanced cytotoxicity of natural killer (NK) and CD8(+) T cells and proliferation of CD40-stimulated B cells. Exogenous IL-21 has antitumor effects in murine models via immunological mechanisms.
David J, Andorsky, John M, Timmerman
openaire   +2 more sources

Interleukin 21: A Key Player in Lymphocyte Maturation

Critical Reviews in Immunology, 2004
The common gamma chain family of cytokine receptors plays a plethora of roles during the early development, activation, and terminal differentiation of the lymphocyte lineages. The most recently identified member of this family, the IL-21R, is expressed to varying degrees on B, T lymphocytes, and natural killer (NK) cells, whereas IL-21, is reportedly ...
Stephen L, Nutt, Jason, Brady, Yoshihiro, Hayakawa, Mark J, Smyth   +3 more
openaire   +2 more sources

Interleukin-21 Inhibits HBV Replication in vitro

Antiviral Therapy, 2014
Background Cytokines are crucial factors in the non-cytolytic antiviral process to inhibit HBV gene expression and replication. Interleukin (IL)-21 has been suggested to play an important role in HBV infection, but it remains unknown whether IL-21 can inhibit HBV replication or how it inhibits HBV replication. Methods In this study, we investigated the
Hai-Jun, Li, Fu-Biao, Kang, Bao-Sheng, Li, Xin-Ying, Yang, Yin-Ge, Zhang, Dian-Xing, Sun   +5 more
openaire   +2 more sources

Interleukin-21 in T cell-mediated diseases.

Discovery medicine, 2009
Interleukin-21 (IL-21), a cytokine produced by activated CD4+ T cells, activated natural killer T cells, and T follicular cells, has been reported to play a crucial role in the tissue-damaging T cell response in various organs, such as gut, skin, pancreas, and joints.
MONTELEONE, GIOVANNI, Sarra, M, PALLONE, FRANCESCO   +2 more
openaire   +2 more sources

Circulating HIV-Specific Interleukin-21

2016
OA ...
Schultz, Bruce T., Teigler, Jeffrey E., Pissani, Franco, Oster, Alexander F., Kranias, Gregory, Alter, Galit, Marovich, Mary, Eller, Michael A., Dittmer, Ulf, Robb, Merlin L., Kim, Jerome H., Michael, Nelson L., Bolton, Diane, Streeck, Hendrik   +13 more
openaire   +1 more source

[Expressions of interleukin-21 and interleukin-22 in Kimura's disease].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2016
To investigate the expressions of interleukin (IL)-21 (IL-21) and IL-22 in patients with Kimura's disease (KD).Expressions of IL-21 and IL-22 were examined immunohistochemically in 36 patients with KD and 7 normal controls. The integral absorbance (IA) of the two groups was compared.
Qingli, Chen, Lulu, Hu, Zhongcheng, Gong, Dwa, Srijana, Xiaopeng, Yin, Zhaoquan, Lin   +5 more
openaire   +1 more source