Results 31 to 40 of about 3,531,639 (330)

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core   +5 more sources

The effect of carbohydrate ingestion on the Interleukin-6 response to a 90-minute run time trial [PDF]

, 2009
Fatigue is a predictable outcome of prolonged physical activity; yet its biological cause remains uncertain. During exercise, a polypeptide messenger molecule interleukin- 6 (IL-6) is actively produced.
Ansley, Les, Barwood, Martin, Eglin, Clare, Robson-Ansley, Paula   +3 more
core   +1 more source

Polymorphisms of interleukin-21 and interleukin-21-receptor genes confer risk for autoimmune thyroid diseases [PDF]

BMC Endocrine Disorders, 2013
The abnormality of interleukin-21 (IL-21)-IL-21-receptor (IL-21R) system has been found in many autoimmune diseases including autoimmune thyroid diseases (AITDs). In this study, we investigated whether polymorphisms of the IL-21 and IL-21R are associated with Graves' disease (GD) and Hashimoto's thyroiditis (HT), two major forms of AITDs, among a ...
Zhang, Jian, Xiao, Wan Xia, Zhu, Yuan Feng, Muhali, Fatuma Said, Xiao, Ling, Jiang, Wen Juan, Shi, Xiao Hong, Zhou, Lian Hua, Zhang, Jin An   +8 more
openaire   +2 more sources

Critical role of Interleukin 21 and T follicular helper cells in hypertension and vascular dysfunction.

JCI Insight, 2019
T and B cells have been implicated in hypertension, but the mechanisms by which they produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce interleukin 21 (IL21) promote germinal center (GC) B cell responses leading to ...
B. Dale, A. Pandey, Yuhan Chen, C. Smart, Fanny Laroumanie, Mingfang Ao, Liang Xiao, A. Dikalova, S. Dikalov, F. Elijovich, Jason D Foss, N. Barbaro, J. P. V. Beusecum, S. Deger, Aseel Alsouqi, H. Itani, A. Norlander, Matthew R. Alexander, Shilin Zhao, T. Ikizler, H. Algood, H. Algood, M. Madhur   +22 more
semanticscholar   +1 more source

Interleukin-17/Interleukin-21 and Interferon-γ producing T cells specific for β2 Glycoprotein I in atherosclerosis inflammation of systemic lupus erythematosus patients with antiphospholipid syndrome

Haematologica, 2019
Systemic lupus erythematosus is frequently associated with antiphospholipid syndrome. Patients with lupus-antiphospholipid syndrome are characterized by recurrent arterial/venous thrombosis, miscarriages, and persistent presence of autoantibodies against
M. Benagiano, M. Borghi, J. Romagnoli, M. Mahler, C. D. Bella, A. Grassi, N. Capitani, G. Emmi, A. Troilo, E. Silvestri, L. Emmi, H. Alnwaisri, Jacopo Bitetti, S. Tapinassi, D. Prisco, C. Baldari, P. Meroni, M. D’Elios   +17 more
semanticscholar   +1 more source

Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures [PDF]

, 2016
Objective To describe changes in immune parameters observed during long-term methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) and explore correlations with simultaneously measured MTX pharmacokinetic (PKC) parameters ...
Hamilton, Robert, Kremer, Joel M., Lawrence, David A., McInnes, Iain B.   +3 more
core   +1 more source

Efficient Interleukin-21 Production by Optimization of Codon and Signal Peptide in Chinese Hamster Ovarian Cells.

Journal of Microbiology and Biotechnology, 2019
Interleukin-21 is a common γ-chain cytokine that controls the immune responses of B cells, T cells, and natural killer cells. Targeting IL-21 to strengthen the immune system is promising for the development of vaccines as well as anti-infection and anti ...
H. Cho, Byung Moo Oh, Jong-Tae Kim, Jeewon Lim, S. Park, Y. Hwang, K. Baek, Bo-Yeon Kim, I. Choi, Hee-Gu Lee   +9 more
semanticscholar   +1 more source

Pathogenic role of interleukin-21 in psoriasis [PDF]

Cell Cycle, 2009
Psoriasis is a chronic inflammatory disease of the skin characterized by keratinocyte hyperplasia and dermal infiltration with inflammatory cells. Driving factors the epidermal hyperplasia in psoriasis are not fully understood, but there is evidence that T cell-derived cytokines can be involved. In this article, we focus on the recent data indicating a
CARUSO, ROBERTA, COSTANZO, ANTONIO, MONTELEONE, GIOVANNI   +2 more
openaire   +3 more sources

Transient Expression of Interleukin-21 in the Second Hit of Acute Pancreatitis May Potentiate Immune Paresis in Severe Acute Pancreatitis

Pancreas, 2019
Objectives Interleukin-21 (IL-21) is a cytokine associated with tissue inflammation, autoimmune and infectious diseases. Organ dysfunction and death can occur in patients with acute pancreatitis (AP) in two distinct clinical phases. Initially, a systemic
J. Thomson, E. Nweke, M. Brand, M. Nel, G. Candy, P. Fonteh   +5 more
semanticscholar   +1 more source

Diagnostic Value Parameters Of Acute Phase Reactances Of Infectious-inflammatory Process In Diagnostics Of Early Neonatal Sepsis [PDF]

, 2018
An advanced progress of clinical neonatology in recent years has enabled to achieve considerable success in newborn management with due respect to both medical treatment and general care, especially in the group of neonates with low body weight at birth.
Bezrukov, L. (Leonid), Koloskova, O. (Olena), Vlasova, O. (Olena)   +2 more
core   +2 more sources