Results 41 to 50 of about 3,088,438 (300)
Cloning and characterization of an isoform of interleukin‐21 [PDF]
FEBS Letters, 2007 Interleukin‐21 (IL‐21) has pleiotropic functions on the cells, which play roles in both innate and acquired immunity, such as T cells, B cells, natural killer (NK) cells and dendritic cells. In this study we identified a novel isoform of IL‐21, IL‐21iso in human and mouse. IL‐21iso might be an alternative splicing variant form and the C‐terminal region
Akemi Araki +6 more
openaire +3 more sources
Definitions, 2020 Interleukin-21 (155 aa, ~18 kDa) is encoded by the human IL21 gene. This protein plays a role in both receptor-mediated signaling and the inflammatory response.
semanticscholar +1 more source
Pathogenic role of interleukin-21 in psoriasis [PDF]
Cell Cycle, 2009 Psoriasis is a chronic inflammatory disease of the skin characterized by keratinocyte hyperplasia and dermal infiltration with inflammatory cells. Driving factors the epidermal hyperplasia in psoriasis are not fully understood, but there is evidence that T cell-derived cytokines can be involved. In this article, we focus on the recent data indicating a
CARUSO, ROBERTA +2 more
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Raman spectroscopic detection of interleukin-10 and angiotensin converting enzyme
Journal of the European Optical Society-Rapid Publications, 2021 In this report we present a confocal Raman system to identify the unique spectral features of two proteins, Interleukin-10 and Angiotensin Converting Enzyme. Characteristic Raman spectra were successfully acquired and identified for the first time to our
Shuo Zhang +4 more
doaj +1 more source
Evaluation of plasma IL-21 as a potential biomarker for type 1 diabetes progression
Frontiers in Immunology, 2023 IL-21 is a multifunctional cytokine linked with the pathophysiology of several autoimmune diseases, including type 1 diabetes. In this study, our aim was to examine plasma IL-21 levels in individuals at different stages of type 1 diabetes progression. We
Anna-Mari Schroderus +18 more
doaj +1 more source
Interleukin-21 Regulates Natural Killer Cell Responses During Mycobacterium tuberculosis Infection. [PDF]
J Infect Dis, 2018 Paidipally P +9 more
europepmc +2 more sources
The role of interleukin-21 in HIV infection [PDF]
Cytokine & Growth Factor Reviews, 2012 Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γ(c)). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the ...
Savita Pahwa +2 more
openaire +3 more sources
Frontiers in Immunology, 2022 Interleukins 4 (IL-4) and 21 (IL-21) belong to the common gamma chain cytokine family which are highly involved in the progression of autoimmune diseases.
Chin Wai Hui +2 more
doaj +1 more source
The Emerging Role of Interleukin-21 in Transplantation [PDF]
Journal of Clinical & Cellular Immunology, 2013 Since its discovery in 2000, IL-21 has been shown to play critical roles in the regulation of both innate and adaptive immune responses. IL-21 is produced predominantly by multiple effector CD4+ T-cell types [T helper 17 (Th17), follicular helper T (TFH), and other activated CD4+ cells] and NKT cells.
Wenhao Chen +3 more
openaire +3 more sources
Polymorphisms of interleukin-21 and interleukin-21-receptor genes confer risk for autoimmune thyroid diseases [PDF]
BMC Endocrine Disorders, 2013 The abnormality of interleukin-21 (IL-21)-IL-21-receptor (IL-21R) system has been found in many autoimmune diseases including autoimmune thyroid diseases (AITDs). In this study, we investigated whether polymorphisms of the IL-21 and IL-21R are associated with Graves' disease (GD) and Hashimoto's thyroiditis (HT), two major forms of AITDs, among a ...
Jian Zhang +8 more
openaire +3 more sources