Results 51 to 60 of about 3,088,438 (300)

Evaluation of Interleukin-21, 23 and 27 mRNA Expression and Protein Level in Liver Transplant Patients

open access: yesIranian Journal of Allergy, Asthma and Immunology, 2018
Cytokines have prominent roles in activating of different T cells and shifting the immune response, in this study the role of three cytokines (IL-21, IL-23 and IL-27) is investigated in the liver transplant rejection.
Afsoon Afshari   +6 more
doaj   +1 more source

Interleukin-21 accelerates thymic recovery from glucocorticoïd-induced atrophy. [PDF]

open access: yesPLoS ONE, 2013
Both physiological and psychological stress cause thymic atrophy via glucocorticoïd (GC)-dependent apoptosis of double-positive (DP) thymocytes. Given the pervasiveness of stress, GC-induced thymic atrophy is arguably the most common type of acquired ...
Moutih Rafei   +3 more
doaj   +1 more source

IL-21–Deficient T Follicular Helper Cells Support B Cell Responses Through IL-27 in Patients With Chronic Hepatitis B

open access: yesFrontiers in Immunology, 2021
Chronic Hepatitis B (CHB) affects over 350 million people worldwide. Current treatment does result in reduced complications; however, a cure (development of antibodies to the S antigen) is not achieved, requiring life-long therapy.
Arshi Khanam   +4 more
doaj   +1 more source

Critical role of Interleukin 21 and T follicular helper cells in hypertension and vascular dysfunction.

open access: yesJCI Insight, 2019
T and B cells have been implicated in hypertension, but the mechanisms by which they produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce interleukin 21 (IL21) promote germinal center (GC) B cell responses leading to ...
B. Dale   +22 more
semanticscholar   +1 more source

IL‐21 regulates macrophage activation in human monocytic THP‐1‐derived macrophages

open access: yesRheumatology & Autoimmunity, 2021
Background: Interleukin‐21 (IL‐21) has a regulatory effect on various immune cells. Its effect on macrophage function remains unclear. Aims: This study aimed to investigate the effect of IL‐21 on the macrophages‐mediated inflammatory response and explore
Leilei Jian   +7 more
doaj   +1 more source

Interleukin-21 in cancer immunotherapy [PDF]

open access: yesOncoImmunology, 2012
Interleukin (IL)-21, a cytokine produced by activated conventional CD4+ T lymphocytes and Natural Killer T cells, drives anti-tumor immunity in the skin and kidney. However IL-21 is also pro-inflammatory in many tissues and promotes colitis-associated colon cancer.
Stolfi, C   +3 more
openaire   +4 more sources

Observational study of Interleukin-21 (IL-21) does not distinguish Kawasaki disease from other causes of fever in children

open access: yesPediatric Rheumatology Online Journal, 2017
Background Kawasaki disease (KD) is a febrile childhood vasculitis of unknown etiology. The diagnosis is highly concerning as over a quarter of children who fail to receive timely treatment with intravenous immunoglobulin (IVIG) will develop coronary ...
Rachel Engelberg   +3 more
doaj   +1 more source

Adoptive Transfer of Interleukin-21-stimulated Human CD8+ T Memory Stem Cells Efficiently Inhibits Tumor Growth

open access: yesJournal of immunotherapy, 2018
Memory stem T (TSCM) cells, a new subset of memory T cells with self-renewal and multipotent capacities, are considered as a promising candidates for adoptive cellular therapy.
Yingshi Chen   +9 more
semanticscholar   +1 more source

Expressions of IL-17, IL-21 and IL-23 in the serum of allergic rhinitis patients [PDF]

open access: yesJournal of Medical Biochemistry, 2011
The present study aimed to investigate the expressions of interleukin-17 (IL-17), IL-21 and IL-23 in the serum of allergic rhinitis (AR) patients and to explore their relationship with special IgE (sFgE) in the serum.
Huang Xuekun   +5 more
doaj  

Interleukin 21 (IL-21)/microRNA-29 (miR-29) axis is associated with natural resistance to HIV-1 infection

open access: yesAIDS (London), 2018
Background: Interleukin-21 (IL-21) modulates HIV-1 infection through the elicitation of different antiviral mechanisms, including Th17 lineage commitment and induction of microRNA (miR)-29, a miRNA endowed with anti-HIV activity.
Paula A S Ortega   +12 more
semanticscholar   +1 more source

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