Results 71 to 80 of about 3,088,438 (300)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latency. [PDF]

PLoS Pathogens, 2015
The human gammaherpesviruses take advantage of normal B cell differentiation pathways to establish life-long infection in memory B cells. Murine gammaherpesvirus 68 (MHV68) infection of laboratory strains of mice also leads to life-long infection in ...
Christopher M Collins, Samuel H Speck
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Interleukin-6 Trajectory and Secondary Infections in Mechanically Ventilated Patients With Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Treated With Interleukin-6 Receptor Blocker

Critical Care Explorations, 2021
Objectives:. To describe the infectious complications and interleukin-6 trajectories in mechanically ventilated patients with coronavirus disease 2019. Design:. Retrospective cohort study. Setting:. ICUs at Washington University-Barnes Jewish Hospital in
M. Cristina Vazquez Guillamet, MD, Hrishikesh S. Kulkarni, MD, MSCI, Kevin Montes, MD, Maanasi Samant, MD, Preet A. Shaikh, MD, Kevin Betthauser, PharmD, Philip A. Mudd, MD, PhD, Daniel Reynolds, MD, Jane O’Halloran, MD, PhD, Patrick Lyons, MD, Colleen McEvoy, MD, Rodrigo Vazquez Guillamet, MD   +11 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Changes in macrophage and inflammatory cytokine expressions during fracture healing in an ovariectomized mice model

BMC Musculoskeletal Disorders, 2021
Background Macrophages and inflammatory cytokines play important roles in bone fracture healing. However, the expression patterns of macrophages and inflammatory cytokines during fracture healing under the condition of postmenopausal osteoporosis have ...
Lin Chen, Shao Cheng, Kanghui Sun, Jing Wang, Xinhua Liu, Yongjian Zhao, Junjie Yang, Dongfeng Zhao, Chunchun Xue, Yuren Tao, Shitian Zhao, Hao Zhang, Sheng Lu, Qi Shi, Yongjun Wang, Bing Shu   +15 more
doaj   +1 more source

Anti-CD20-interleukin-21 fusokine targets malignant B cells via direct apoptosis and NK-cell-dependent cytotoxicity.

Blood, 2017
In spite of newly emerging therapies and the improved survival of patients with non-Hodgkin lymphoma (NHL), relapses or primary refractory disease are commonly observed and associated with dismal prognosis.
Shruti Bhatt, S. Parvin, Yu Zhang, Hyun-Mi Cho, K. Kunkalla, F. Vega, J. Timmerman, Seung-Uon Shin, J. Rosenblatt, I. Lossos   +9 more
semanticscholar   +1 more source

Reversing Gut Damage in HIV Infection: Using Non-Human Primate Models to Instruct Clinical Research

EBioMedicine, 2016
Antiretroviral therapy (ART) has led to dramatic improvements in the lives of HIV-infected persons. However, residual immune activation, which persists despite ART, is associated with increased risk of non-AIDS morbidities.
Rosalie Ponte, Vikram Mehraj, Peter Ghali, Anne Couëdel-Courteille, Rémi Cheynier, Jean-Pierre Routy   +5 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source