Results 71 to 80 of about 3,531,639 (330)
The role of interleukin-21 in HIV infection [PDF]
Cytokine & Growth Factor Reviews, 2012 Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γ(c)). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the ...
Suresh, Pallikkuth +2 more
openaire +2 more sources
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. [PDF]
, 1996 The mechanism by which the mammalian mother accepts the implanting fetus as an allograft remains unexplained, but is likely to be the result of a combination of factors.
Abrams, JS +5 more
core +1 more source
Cellular and molecular mediators of bone metastatic lesions [PDF]
, 2018 Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia +3 more
core +2 more sources
Interleukin-21-Mediated TLR4 Activation in Celiac Disease [PDF]
Digestive Diseases and Sciences, 2013 Dear Editor, We read with great interest the recent contribution by Eiro et al. [1]. They reported that celiac disease (CD) patients with high levels of toll-like receptor 4 (TLR4) showed high levels of interleukins (IL-1, IL-6, IL-8, and IL-17) as well as transcription factors. However, unfortunately, they did not analyze the expression of IL-21.
Se Jin, Park, Jae Il, Shin
openaire +3 more sources
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen +6 more
wiley +1 more source
The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response [PDF]
, 2010 The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function.
Cockburn, Emma +4 more
core
Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice [PDF]
, 2016 Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary ...
Andreas J.R. Habenicht +13 more
core +1 more source
Interleukin-21 promotes thymopoiesis recovery following hematopoietic stem cell transplantation
Journal of Hematology & Oncology, 2017 BackgroundImpaired T cell reconstitution remains a major deterrent in the field of bone marrow (BM) transplantation (BMT) due to pre-conditioning-induced damages inflicted to the thymi of recipient hosts.
A. Tormo +7 more
semanticscholar +1 more source