Results 261 to 270 of about 541,619 (302)
A balance of interleukin-12 and -23 in cancer
Trends in Immunology, 2013 Interleukin (IL)-12 and IL-23 share the IL-12p40 molecule. IL-12 promotes T helper (Th)1 immunity and IL-23 promotes Th17 immunity, and it has recently become apparent that the balance between IL-12 and IL-23 is important in carcinogenesis. A series of studies demonstrated that, where tumor initiation, growth, and metastasis are concerned, IL-12 may ...
Ngiow, Shin Foong +2 more
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Interleukin-12 and interleukin-23 inhibition in psoriatic arthritis.
Clinical and experimental rheumatology, 2015 The cytokines interleukin (IL)-12 and interleukin (IL)-23 have been implicated variously in the pathogenesis of psoriasis and psoriatic arthritis (PsA). By corollary, the IL-12/23 inhibitor, Ustekinumab has been developed as an approved therapeutic for the skin and musculoskeletal syndrome of psoriasis / PsA.
Hanna J, Johnsson, Iain B, McInnes
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Biochemical and Biophysical Research Communications, 2022
Interaction between the pro-inflammatory cytokine interleukin-23 (IL-23) and IL-23 receptor (IL-23R) is related to the development of inflammatory autoimmune diseases such as psoriasis, inflammatory bowel disease, and Crohn's disease. In this study, we conducted systematic evolution of ligands by exponential enrichment (SELEX) for in vitro selection ...
Yukio Takamori +8 more
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Interaction between the pro-inflammatory cytokine interleukin-23 (IL-23) and IL-23 receptor (IL-23R) is related to the development of inflammatory autoimmune diseases such as psoriasis, inflammatory bowel disease, and Crohn's disease. In this study, we conducted systematic evolution of ligands by exponential enrichment (SELEX) for in vitro selection ...
Yukio Takamori +8 more
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Interleukin-17 and interleukin-23 in patients with polymyositis and dermatomyositis
Scandinavian Journal of Rheumatology, 2011To analyse the concentration of interleukin (IL)-17 and IL-23 in serum and ex vivo culture supernatant of peripheral blood mononuclear cells (PBMCs) from patients with polymyositis (PM) and dermatomyositis (DM) compared with healthy controls (HC).Enzyme-linked immunosorbent assay (ELISA) was used to analyse the concentration of IL-17 and IL-23 from 25 ...
H, Shen, L, Xia, J, Lu, W, Xiao
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Interleukin-12, interleukin-23, and psoriasis: Current prospects
Journal of the American Academy of Dermatology, 2007The clinical phenotype of psoriasis results from infiltration of T cells in the skin and elaboration of inflammatory cytokines. Interleukin (IL)-12 and, more recently, IL-23 have been implicated in the pathogenesis of psoriatic lesions. New therapies, including a monoclonal antibody against a subunit shared by IL-12 and IL-23, have been developed to ...
Dorothea C, Torti, Steven R, Feldman
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The critical role of interleukin-23 in spondyloarthropathy
Molecular Immunology, 2014The spondyloarthropathies represent highly enigmatic conditions and although their clinical features, anatomical distribution of disease and genetic predisposing factors have been known for some time, a unified concept of the basic pathobiology underlying these illnesses has remained undefined.
Jonathan P, Sherlock +2 more
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Interleukin-23: A New Atherosclerosis Target
Journal of Interferon & Cytokine Research, 2018Accumulating evidence has shown that atherosclerosis is an inflammatory disease. The pathogenesis of atherosclerosis has been confirmed to involve an imbalance in anti-inflammatory/proinflammatory processes. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of the IL-23p19 and IL-12p40 subunits of the IL-12 family. Experiments show that IL-23
Wenjing, Liu +3 more
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Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy
Current Opinion in Infectious Diseases, 2006Interleukin-12 is a heterodimeric cytokine and an important mediator of the cellular immune response. The recent discovery of the novel cytokine interleukin-23 has led to a re-evaluation of interleukin-12 biology, as both cytokines use a common p40 subunit.
Edward P, Bowman +2 more
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Interleukin (IL)-12/23 and IL-23 Inhibitors
2022Biologic therapies have transformed the treatment of moderate-to-severe psoriasis. This is a rapidly evolving field, with several new monoclonal antibody medications reaching the market over the last few years. A number of classes of biologic agents now exist, corresponding to the underlying cytokine target of the antibody therapy. The interleukin (IL)-
Earnshaw, Charles, Warren, Richard B.
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Expressed gene sequences of the equine cytokines interleukin-17 and interleukin-23
Veterinary Immunology and Immunopathology, 2010This report describes the initial cloning and characterization of the equine interleukin-17 (IL-17) expressed gene sequence from mRNA obtained from equine intestinal tissue and interleukin-23 (IL-23) expressed gene sequence from mRNA obtained from equine peripheral blood mononuclear cells.
Dannielle, Tompkins +3 more
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