Results 121 to 130 of about 429,593 (156)

Interleukin‐33 induces interleukin‐17F in bronchial epithelial cells

Allergy, 2012
AbstractBackgroundIL‐33 is clearly expressed in the airway of patients with asthma, but its role in asthma has not yet been fully understood. IL‐17F is also involved in the pathogenesis of asthma. However, the regulatory mechanisms of IL‐17F expression remain to be defined.
J, Fujita, M, Kawaguchi, F, Kokubu, G, Ohara, K, Ota, S-K, Huang, Y, Morishima, Y, Ishii, H, Satoh, T, Sakamoto, N, Hizawa   +10 more
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Interleukin-33 in atopic dermatitis

Journal of Dermatological Science, 2019
Atopic dermatitis (AD) is characterized by pruritus, barrier disruption, and inflammationincluding type 2 cytokine production. Interleukin-33 (IL-33) is an inflammatory cytokine that is over-expressed in the keratinocytes of patients with AD. IL-33 transgenic mice, which express IL-33 specifically in keratinocytes, spontaneously develop AD-like eczema,
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Interleukin-33 and Atherosclerosis

2011
Interleukin (IL)-33 (also known as IL-1 F11) is a newly identified member of the IL-1 cytokine family with close amino acid sequence homology to IL-18 [1]. The human and mouse sequences for IL-33 have been mapped to chromosomes 9 (9p24.1) and 19 (19qc1), encoding proteins of 270 and 266 amino acids respectively.
Foo Y. Liew, Ashley M. Miller
openaire   +1 more source

Interleukin-33: increasing role in dermatological conditions

Archives of Dermatological Research, 2016
Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan IL-1 family receptor.
Balato, Anna, Raimondo, Annunziata, Balato, Nicola, Ayala, Fabio, LEMBO, Serena   +4 more
openaire   +5 more sources

Role of interleukin 33 in human immunopathology

Annals of the Rheumatic Diseases, 2010
Interleukin 33 (IL33) is a recently described member of the IL1 superfamily of cytokines. Originally defined on the basis of T-cell subset differentiation, IL33 is now recognised to mediate a wider role in regulating components of the innate immune response also, particularly via mast cell activation.
G E J, Murphy, D, Xu, F Y, Liew, I B, McInnes   +3 more
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Tranilast inhibits interleukin-33 production by macrophages

European Journal of Pharmacology, 2018
Tranilast is an anti-allergy medication that inhibits the release of chemical mediators such as histamine. However, the mechanisms underlying its anti-allergy effects are not fully understood. Interleukin (IL)-33, a novel member of the IL-1 cytokine family, promotes T helper type 2 immune responses and plays a pathogenic role in allergic disorders.
Sachiko, Hiraide, Yoshiki, Yanagawa, Kenji, Iizuka   +2 more
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Association of serum interleukin‐33 level and the interleukin‐33 genetic variant with Japanese cedar pollinosis

Clinical & Experimental Allergy, 2008
SummaryBackground IL‐33, an IL‐1‐like cytokine, is a ligand for IL1RL1, which is an important effector molecule of type 2 T helper responses. Although IL‐33/IL1RL1 interaction has been suggested to be important in induction of allergic airway inflammation, serum levels of IL‐33 and the genetic influences of the polymorphisms of IL‐33 in human ...
M, Sakashita, T, Yoshimoto, T, Hirota, M, Harada, K, Okubo, Y, Osawa, S, Fujieda, Y, Nakamura, K, Yasuda, K, Nakanishi, M, Tamari   +10 more
openaire   +2 more sources

Interleukin-33: a regulator of basophils

Blood, 2009
The cytokine network controlling basophils has been extended to interleukin-33. This commentary provides an update and summary on this emerging concept.
openaire   +2 more sources

Interleukin-33 safeguards neutrophils in sepsis

Nature Medicine, 2010
Cytokines have a fundamental role in orchestrating innate immune responses to bacterial infections. Interleukin-33 (IL-33) is now shown to protect from sepsis by promoting neutrophil influx into the focus of infection (pages 708–712).
Thierry Roger, Thierry Calandra
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Special aspects of interleukin-33 and the IL-33 receptor complex

Seminars in Immunology, 2013
Interleukin-33 (IL-33) is an unconventional member of the IL-1 family: it is a dual function cytokine. Many different cell types, tissue cells and leukocytes, produce IL-33 either constitutively or after stimulation and release it by a poorly defined molecular mechanism.
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