Results 241 to 250 of about 728,843 (299)

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Epithelial Interleukin-1 Receptor-Like-1 Activation Is Contingent on Interleukin-33 Isoforms and Asthma-Related Receptor Variation. [PDF]

Clin Exp Allergy
Portelli MA, Ketelaar ME, Bates S, Csomor E, Shaw D, Emsley J, Brightling C, Hall I, Affleck K, Edwards M, Nawijn MC, Koppelman GH, Van Oosterhout AJ, Sayers I.   +13 more
europepmc   +1 more source

Programmable Semi‐Interpenetrating Living Materials With Robust Stability for Versatile Bioremediation and Biotherapeutics

Advanced Science, EarlyView.
A semi‐interpenetrating engineered living material (sIHSELM), fabricated via thermosensitive hydroxybutyl chitosan and covalent protein self‐assembly, demonstrates exceptional mechanical properties and environmental stability. Shielding bacteria from harsh conditions, sIHSELM exhibits remarkable efficacy in ulcerative colitis treatment and pollutants ...
Zixian Bao, Shengfeng Yang, Dandan Hu, Jiezheng Liu, Bo Jiang, Xinyue Sui, Qingsheng Qi, Lai Li, Guang Zhao   +8 more
wiley   +1 more source

Interleukin-33 mediated regulation of microRNAs in human cord blood-derived mast cells: Implications for infection, immunity, and inflammation. [PDF]

PLoS One
Bakhashab S, Banafea GH, Ahmed F, Bagatian N, Subhi O, Schulten HJ, Pushparaj PN.   +6 more
europepmc   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression. [PDF]

Nat Commun
Park JH, Mortaja M, Son HG, Zhao X, Sloat LM, Azin M, Wang J, Collier MR, Tummala KS, Mandinova A, Bardeesy N, Semenov YR, Mino-Kenudson M, Demehri S.   +13 more
europepmc   +1 more source

Biomimetic Polymerization of Tellurocysteine: Breaking the Natural Amino Acid Radioprotection Limitation

Advanced Science, EarlyView.
Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen, Hanjie Zhu, Yue Zhang, Yuqing Qiao, Ruotong Deng, Huaping Xu, Wei Cao   +6 more
wiley   +1 more source

Therapeutic targeting of full-length interleukin-33 protein levels with cell-permeable decoy peptides attenuates fibrosis in the bleomycin model in vivo. [PDF]

J Pharmacol Exp Ther
Atamas SP, Lockatell V, Todd NW, Papadimitriou JC, Rus V, Lugkey KN, Vogel SN, Toshchakov VY, Luzina IG.   +8 more
europepmc   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Exploring the Impact of IL-33 Gene Polymorphism (rs1929992) on Susceptibility to Chronic Spontaneous Urticaria and Its Association with Serum Interleukin-33 Levels. [PDF]

Int J Mol Sci
Dobrican-Băruța CT, Deleanu DM, Iancu M, Muntean IA, Nedelea I, Bălan RG, Procopciuc LM, Filip GA.   +7 more
europepmc   +1 more source