Results 71 to 80 of about 113,408 (308)

Anti-Inflammatory Effect of Tacrolimus/Hydroxypropyl-β-Cyclodextrin Eye Drops in an Endotoxin-Induced Uveitis Model

Pharmaceutics, 2021
Background: Uveitis is an infrequent disease which constitutes a major cause of ocular morbidity. Correct management is essential, being corticosteroids its cornerstone.
Xurxo García-Otero, Cristina Mondelo-García, Francisco González, Roman Perez-Fernandez, Leandro Avila, Jose Ramón Antúnez-López, Miguel González-Barcia, Alfredo Adan, Pablo Aguiar, Francisco J. Otero-Espinar, Maria A. Bermúdez, Anxo Fernández-Ferreiro   +11 more
doaj   +1 more source

Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]

, 2013
Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Systemic interleukins levels in community-acquired pneumonia and their association with adverse outcomes

Romanian Journal of Laboratory Medicine, 2019
Introduction: Community-acquired pneumonia (CAP) is still one of the major causes of morbidity and mortality worldwide. Pro-inflammatory and anti-inflammatory interleukins have been studied to elucidate the role that inflammation plays in its ...
Tripon Raluca Elena, Neagoe Ioana Berindan, Budisan Livia, Pop Tudor Lucian, Cristea Victor, Stanca Liana Maria, Lupse Mihaela Sorina   +6 more
doaj   +1 more source

The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease

İstanbul Medical Journal, 2022
Introduction:Pregnancy is considered a low-grade inflammatory state presented with increased levels of pro-inflammatory markers. Despite the well-recognized association between inflammation and kidney injury, there is still a lack of available data ...
Emel Sağlam, Bennur Esen, Saadet Pilten, Vüsale Gözütok, Ahmet Engin Atay   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Relationship between disorders of adipose tissue hormones and interleukins in patients with hypertension and comorbid pathology

Zaporožskij Medicinskij Žurnal, 2017
The purpose of research – was to improve the efficiency of diagnostics of arterial hypertension (AH) with comorbid disorders (diabetes mellitus (DM) and obesity) by studying hormones of adipose tissue (leptin and adiponectin) and the inflammatory markers
B. O. Shelest
doaj   +1 more source

PANCREATIC INVOLVEMENT IN LEPTOSPIROSIS [PDF]

Journal of IMAB, 2005
The research includes 84 patients with leptospirosis treated in Clinic at Infectious Diseases – Pleven. Mild course in 52,38%, moderate in 19,05%, and severe in 28,57% are established. Serum amylase level has been investigated in 37 cases.
Maria Atanasova, Galya I. Gancheva
doaj   +1 more source

Population mechanics: A mathematical framework to study T cell homeostasis [PDF]

, 2017
Unlike other cell types, T cells do not form spatially arranged tissues, but move independently throughout the body. Accordingly, the number of T cells in the organism does not depend on physical constraints imposed by the shape or size of specific ...
A Singer, AA Freitas, AE Troy, AK Sewell, AM Marleau, AR Khaled, AW Goldrath, AW Goldrath, B Seddon, B Stockinger, B Stockinger, BK Cho, C King, CC Ku, CD Surh, CD Surh, CD Surh, CF Arias, DH Busch, E Hernandez-Garcia, EN Naumova, ER Stirk, ER Stirk, G Cui, G Hardin, GL Stritesky, J Geginat, J Hasbold, JA Vano, JD Miller, JM Weaver, JN Mandl, JT Tan, K Murali-Krishna, K Takada, KA Smith, L Klein, L Klein, L Swainson, LC Osborne, LK Selin, M Matsuoka, M Prabhakar, M Prlic, M Scheffer, MS Anderson, N Rapin, O Boyman, P Marrack, P Marrack, PL Johnson, R Arens, R Mazzucchelli, RA Armstrong, RB Holt, RJ Boer de, S Aggarwal, S Crotty, S Hou, S Smale, SC Jameson, SE Henrickson, SJ Turner, SP Berzins, T Boehm, TJ Fry, TJ Fry, TK Starr, V Vezys, VS Mahajan, Y Sawa, YN Naumov   +71 more
core   +3 more sources