Capturing intermediate filament networks [PDF]
eLife, 2022 Mapping intermediate filaments in three dimensions reveals that the organization of these filaments differs across cell types.
Pierre A Coulombe
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Data-constrained Magnetohydrodynamic Simulation of an Intermediate Solar Filament Eruption [PDF]
The Astrophysical Journal, 2023 Solar eruptive activities could occur in weak magnetic field environments and over large spatial scales, which are especially relevant to eruptions involving intermediate or quiescent solar filaments.
Yang Guo +7 more
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Molecular Interactions Driving Intermediate Filament Assembly [PDF]
Cells, 2021 Given the role of intermediate filaments (IFs) in normal cell physiology and scores of IF-linked diseases, the importance of understanding their molecular structure is beyond doubt. Research into the IF structure was initiated more than 30 years ago, and
Pieter-Jan Vermeire +6 more
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Definitions, 2020 A class of tough protein filaments (including keratin filaments, neurofilaments, desmin, and vimentin) that measure 8-10 nm in thickness and comprise part of the cytoskeleton of the cytoplasm of most eukaryotic cells; so named because they are ...
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Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions [PDF]
eLife, 2023 Intermediate filaments (IFs) are major components of the metazoan cytoskeleton. A long-standing debate concerns the question whether IF network organization only reflects or also determines cell and tissue function.
Florian Geisler +5 more
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Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter [PDF]
Cells, 2021 This essay focuses on the role of plectin and its various isoforms in mediating intermediate filament (IF) network functions. It is based on previous studies that provided comprehensive evidence for a concept where plectin acts as an IF recruiter, and ...
Gerhard Wiche
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The intermediate filament network in cultured human keratinocytes is remarkably extensible and resilient. [PDF]
PLoS ONE, 2008 The prevailing model of the mechanical function of intermediate filaments in cells assumes that these 10 nm diameter filaments make up networks that behave as entropic gels, with individual intermediate filaments never experiencing direct loading in ...
Douglas Fudge +5 more
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Withaferin a alters intermediate filament organization, cell shape and behavior. [PDF]
PLoS ONE, 2012 Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. Based upon its affinity for vimentin, it has been proposed that WFA can be used as an anti-tumor
Boris Grin +6 more
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An in vivo intermediate filament assembly model
Mathematical Biosciences and Engineering, 2008 A model is developed to study the in vivo intermediate filament organization in terms of repartition between four different structural states: soluble proteins, particles, short, and long filaments. An analysis is conducted, showing that the system has a
Stéphanie Portet, Julien Arino
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Intermediate Filament Protein BFSP2 Controls Spindle Formation via HSC70‐Mediated Stabilization of CLTC During Oocyte meiosis [PDF]
Advanced ScienceAs a major component of the cytoskeleton, intermediate filaments are generally considered to play a supporting role in mitotic cells. They also take part in the regulation of cell motility, proliferation, differentiation, and apoptosis.
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
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