Results 71 to 80 of about 164,981 (291)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Formation of an Intermediate Filament Driven by Small-scale Magnetic Reconnection
The Astrophysical Journal, 2023 We present the formation process of a filament in NOAA active region 12765 from 2020 June 5 to 8, using observations from the New Vacuum Solar Telescope, the Solar Dynamics Observatory, and the Global Oscillation Network Group. We found that intermittent
Xia Sun +11 more
doaj +1 more source
The mechanical response of semiflexible networks to localized perturbations
, 2005 Previous research on semiflexible polymers including cytoskeletal networks in cells has suggested the existence of distinct regimes of elastic response, in which the strain field is either uniform (affine) or non-uniform (non-affine) under external ...
A. J. Levine +7 more
core +2 more sources
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
On the origin of non self-gravitating filaments in the ISM [PDF]
, 2013 {Filaments are ubiquitous in the interstellar medium as recently emphasized by Herschel, yet their physical origin remains elusive} {It is therefore important to understand the physics of molecular clouds to investigate how filaments form and what is the
Hennebelle, Patrick
core +6 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung +7 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source
Assembly mechanisms of the bacterial cytoskeletal protein FilP
Life Science Alliance, 2019 FilP is a coiled-coil protein that self-assembles into striated filaments and meshwork that shares structural and biochemical characteristics with metazoan intermediate filaments. Despite low-sequence homology, the intermediate filament (IF)–like protein
Ala Javadi +4 more
doaj +1 more source
Alternative mRNA splicing from the glial fibrillary acidic protein (GFAP) gene generates isoforms with distinct subcellular mRNA localization patterns in astrocytes. [PDF]
PLoS ONE, 2013 The intermediate filament network of astrocytes includes Glial fibrillary acidic protein (Gfap) as a major component. Gfap mRNA is alternatively spliced resulting in generation of different protein isoforms where Gfapα is the most predominant isoform ...
Rune Thomsen +3 more
doaj +1 more source
Intermediate filaments in cardiomyopathy [PDF]
Biophysical Reviews, 2018 Intermediate filament (IF) proteins are critical regulators in health and disease. The discovery of hundreds of mutations in IF genes and posttranslational modifications has been linked to a plethora of human diseases, including, among others, cardiomyopathies, muscular dystrophies, progeria, blistering diseases of the epidermis, and neurodegenerative ...
Mary, Tsikitis +4 more
openaire +2 more sources