Results 151 to 160 of about 104,417 (205)
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Cytoskeleton | Intermediate Filament Linker Proteins: Plectin and BPAG1
2021Owing to their structural diversity, functional versatility, and broad interaction profiles, intermediate filament linker proteins play a key role in the organization and dynamics of the cytoskeleton. As such they are involved in many fundamental cellular processes and play an important role in human diseases.
Wiche, Gerhard, Castanon, Maria J.
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Intermediate Filament Protein Structure Determination
2004Publisher Summary X-ray crystallography is one of the few experimental methods that makes possible to study intermediate filament (IF) structure at atomic resolution; however, the prerequisite for a crystallographic analysis is the ability to produce macroscopic, well-ordered crystals.
Sergei V, Strelkov +3 more
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Evolutionary aspects in intermediate filament proteins
Current Opinion in Cell Biology, 2015Intermediate filament (IF) proteins, together with tubulins and actins, constitute the majority of cytoskeletal proteins in metazoans. Proteins of the IF family fulfil increasingly diverse functions but share common structural features. Phylogenetic analysis within the metazoan lineage traces back their origin to a common lamin-like ancestor.
Annette, Peter, Reimer, Stick
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Implications of intermediate filament protein phosphorylation
Cancer and Metastasis Review, 1996Intermediate filament (IF) proteins, a large family of tissue specific proteins, undergo several posttranslational modifications, with phosphorylation being the most studied modification. IF protein phosphorylation is highly dynamic and involves the head and/or tail domains of these proteins, which are the domains that impart most of the structural ...
N O, Ku, J, Liao, C F, Chou, M B, Omary
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Intermediate filament protein evolution and protists
Cytoskeleton, 2018AbstractMetazoans evolved from a single protist lineage. While all eukaryotes share a conserved actin and tubulin‐based cytoskeleton, it is commonly perceived that intermediate filaments (IFs), including lamin, vimentin or keratin among many others, are restricted to metazoans. Actin and tubulin proteins are conserved enough to be detectable across all
Harald Preisner +3 more
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Intermediate Filament-Associated Proteins
1990Intermediate filaments (IF) comprise a set of ~ 10-nm-diameter cytoskeletal filaments that are distributed throughout the cytoplasm from the level of the nuclear surface to the region of the plasma membrane in most eukaryotic cells (Ishikawa et. al., 1968; Traub, 1985a; Wang et. al., 1985; Goldman et. al., 1986).
Hsi-Yuan Yang +2 more
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Crystallographic Studies of Intermediate Filament Proteins
2017Intermediate filaments (IFs), together with microtubules and actin microfilaments, are the three main cytoskeletal components in metazoan cells. IFs are formed by a distinct protein family, which is made up of 70 members in humans. Most IF proteins are tissue- or organelle-specific, which includes lamins, the IF proteins of the nucleus.
Dmytro, Guzenko +2 more
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Myogenesis and the Intermediate Filament Protein, Nestin
Developmental Biology, 1994We show that the intermediate filament protein nestin is expressed in myogenic cells and that multiple mechanisms regulate nestin expression at different stages of myogenesis. Cultured embryonic, fetal, and neonatal mouse limb myoblasts initially expressed nestin in the absence of the four muscle regulatory factors (MRFs) of the MyoD family, whereas ...
A M, Kachinsky +2 more
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A new neuronal intermediate filament protein
Trends in Neurosciences, 1989It would be an understatement to say that the vertebrate nervous system appears complex. The characterization and classification of its components rely, in addition to its gross anatomy, on analyses of the differential expression of cytoskeletal and other cellular structures and products.
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Molecular Phylogeny of Metazoan Intermediate Filament Proteins
Journal of Molecular Evolution, 1998We have cloned cytoplasmic intermediate filament (IF) proteins from a large number of invertebrate phyla using cDNA probes, the monoclonal antibody IFA, peptide sequence information, and various RT-PCR procedures. Novel IF protein sequences reported here include the urochordata and nine protostomic phyla, i.e., Annelida, Brachiopoda, Chaetognatha ...
Erber, A. +3 more
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