Results 231 to 240 of about 948,768 (269)

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Inflammation and Immune Mediators in the Context of Atherosclerotic Cardiovascular Disease and Percutaneous Coronary Intervention: Implications for Therapeutics. [PDF]

Med Sci (Basel)
Chandrasekharan K, Saha P, Merinopoulos I, Eccleshall S, Smith JGW, Vassiliou VS.   +5 more
europepmc   +1 more source

Non-classical and intermediate monocytes in relapsing-remitting multiple sclerosis

, 2018
Schroeder, S. D., Lee, De-Hyung, Pfeifenbring, Sabine, Stadelmann, Christine, Linker, Ralf Andreas, Waschbisch, Anne   +5 more
openaire   +1 more source

Caveola and Its Resident Proteins, Caveolin-1 and -2, Play Critical Roles in the Pathogenesis of nAMD and PCV. [PDF]

Invest Ophthalmol Vis Sci
Yu RMC, Oguz G, Fu NY, Shihabuddeen WA, Cheung C, Wang X, Wong TY, Cheung CMG, Ramasamy A, Yanagi Y.   +9 more
europepmc   +1 more source

Dysregulated myelopoiesis and enhanced glutaminase-dependent neutrophil survival in preclinical obesity. [PDF]

Immunohorizons
Babcock M, Lechner A, Drolet J, Agostini L, Weinstock R, Urao N.   +5 more
europepmc   +1 more source

Monocytes Display Altered Inflammatory Profiles in Individuals with Diabetic Foot Ulcers Indicating Monocyte Dysfunction. [PDF]

Eur J Immunol
Marimuthu R, Medbury HJ, Baraz R, Vicaretti M, Lau SL, Gunton JE, Li S, Williams H.   +7 more
europepmc   +1 more source

Type I IFN signaling shapes subset-specific monocyte fates in the injured myocardium. [PDF]

J Clin Invest
Sakalli ET, Rizzo G, Zernecke A, Campos Ramos G.   +3 more
europepmc   +1 more source

Phenotypic and functional heterogeneity of intermediate monocytes in healthy adults.

, 2015
Human blood monocytes are currently classified into three subsets: CD14++CD16- “Classical”, CD14++CD16+ “Intermediate” and CD14+CD16++ “Non-Classical”. Distinct functional differences between Classical and Non-Classical have been described but the role of Intermediate monocytes is less clear.
Connaughton, Eanna
openaire   +2 more sources

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Impaired LPS tolerance in monocytes of coronary atherosclerosis patients is associated with the intermediate subset

Journal of Leukocyte Biology
Abstract Endotoxin tolerance in monocytes is a mechanism that reduces the secretion of inflammatory cytokines upon repeated pathogen exposure, thereby protecting tissues from hyperinflammation. Previously, we demonstrated that monocytes from patients with asymptomatic carotid atherosclerosis exhibit impaired LPS tolerance. In this study,
Dmitry Zybin, Popov Mikhail, Nikita G Nikiforov   +2 more
exaly   +3 more sources