Results 61 to 70 of about 235,829 (264)

Some advantages of three-layer medium-density fibreboard as compared to the traditional single-layer one

Journal of Wood Science, 2019
The aim of the study was to develop three-layer medium-density fibreboard (MDF) manufacture by adding the coarse fibres in the middle layer, like three-layer particleboard.
Turgay Akbulut, Nadir Ayrilmis
doaj   +1 more source

Current state of the government bond market in the Russian Federation

Путеводитель предпринимателя, 2020
The article reveals the main current trends of the government bond market in the Russian Federation. Various factors that influence the state bond market were studied. External factors included geopolitical risks, rating actions, monetary policy of world
M. N. Lakoza
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Palladium-catalyzed remote internal C(sp 3)−H bond chlorination of alkenes

Nature Communications
C(sp 3)–Cl bonds are present in numerous biologically active molecules and can also be used as a site for diversification by substitution or cross-coupling reactions.
Yao-Xin Wang, Zhen Wang, Xiao-Hui Yang
doaj   +1 more source

PENGARUH BAHAN PENGAWETAN PHOXIM TERHADAP SIFAT PAPAN PARTIKEL KAYU KARET (hevea brasiliensis) (effect of phoxim preservation on the properties of rubber wood particleboard (hevea brasiliensis))

Jurnal Penelitian Hasil Hutan (Journal of Forest Products Research), 2017
The objectives of the study was to determine the effect of phoxim on the properties of rubber wood particleboard (Hevea brasiliensis ) phoxim concentration used were 0.05,1, 1.5 and 2 % based on particle dry weight.
Rodjak Memed, I M Sulastiningsih, Paribotro Sutigno   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

International Bond Return Predictability

, 2021
We study time-varying risk premia across international bond- and equity markets by running predictive regressions of excess returns. We nd that the single factor of Cochrane and Piazzesi (2005) and global factor of Dahlquist and Hasseltoft (2013) have lost some of their predictive power in later years, but they both individually and jointly predict ...
Elnan, André Lerberg, Folker, Alexander Willis   +1 more
openaire   +1 more source