Results 61 to 70 of about 1,101,834 (300)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Particle size and lime addiction on properties of wood-cement composites produced by the method of densification by vibro compaction

open access: yesCiência Rural
: This paper aimed to evaluate the effects of particle size and the use of lime as a pretreatment of Pinus spp wood particles on the production of wood-cement composites by vibro-compaction densification.
Rafael da Rosa Azambuja   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Modeling rock fragmentation by coupling Voronoi diagram and discretized virtual internal bond

open access: yesTheoretical and Applied Mechanics Letters, 2020
The rock fragmentation involves the inter-block and the intra-block fracture. A simulation method for rock fragmentation is developed by coupling Voronoi diagram (VD) and discretized virtual internal bond (DVIB). The DVIB is a lattice model that consists
Sai Liu, Zhennan Zhang
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Proposal for Bond Strength Considering Bond Characteristics of Beam Flexural Rebar on Interior Beam-Column Joints. Part I: Focusing on Concrete Compressive Strength

open access: yesInternational Journal of Concrete Structures and Materials
The bond characteristic of beam longitudinal rebar penetrating reinforced concrete beam-column interior joints under cyclic loading is influenced by various factors such as compressive strength of concrete, yield strength of main rebar, diameter, and ...
Min-Su Jo   +6 more
doaj   +1 more source

Observation of pendular butterfly Rydberg molecules

open access: yes, 2016
Obtaining full control over the internal and external quantum states of molecules is the central goal of ultracold chemistry and allows for the study of coherent molecular dynamics, collisions and tests of fundamental laws of physics.
Eichert, Tanita   +6 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Unveiling the photophysics of thiourea from CASPT2/CASSCF potential energy surfaces and singlet/triplet excited state molecular dynamics simulations

open access: yes, 2019
This work describes the decay mechanism of photoexcited thiourea, both in gas phase and in solution, from the information inferred from the topography of the excited and ground state potential energy surfaces and mixed singlet/triplet quantum classical ...
Corral, Ines   +3 more
core   +1 more source

Microwave and tunable far-infrared laser spectroscopy of the ammonia–water dimer [PDF]

open access: yes, 1992
Microwave and far-infrared spectra of the H3N–HOH dimer have been recorded from 36 to 86 GHz and 520 to 800 GHz with a planar supersonic jet/tunable laser sideband spectrometer.
Blake, Geoffrey A.   +3 more
core   +1 more source

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