Results 71 to 80 of about 1,101,834 (300)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Effect of vibration on the interface properties of welded steel joints and filled concrete in steel pipes

Scientific Reports
Concrete-filled steel tubes (CFSTs) have been increasingly utilized in engineering due to their excellent mechanical properties. Ensuring a solid bond between a steel tube and concrete is essential for optimizing their synergistic effect.
Nianchun Deng, Haoxu Li, Jingyao Ni, Xiuning Peng, Guohua lv, Zhaotao Chen   +5 more
doaj   +1 more source

Risk and return in international corporate bond markets [PDF]

Journal of International Financial Markets, Institutions and Money, 2019
Abstract Corporate bond returns in major developed economies increase with lower ratings and higher residual maturity. The performance of various factor models featuring corporate, sovereign and equity markets as factors suggests that the corporate bond factor plays a dominant role in explaining the variation of corporate bond returns.
Bekaert, Geert, De Santis, Roberto A.
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

ANALISIS PENGARUH FAKTOR INTERNAL EMITEN TERHADAP BAGI HASIL INVESTOR PADA OBLIGASI SYARIAH MUDHARABAH DI INDONESIA

Jurnal Ekonomi Akuntansi dan Manajemen, 2015
This study aims to analyze the influence of internal factors of emitens that affect the investors profit-sharing to the mudharabah islamic bond in Indonesia.
Sri Rahayu, Isti Fadah, Novi Puspitasari
doaj  

Bonding Performance of Lithium Disilicate Veneers to Bioactive and Conventional Resin Cores using three types of luting agent: an in vitro study

Al-Rafidain Dental Journal
Aims: The present study aimed to evaluate the shear bond strength (SBS) and internal adaptation of lithium disilicate veneers bonded to bioactive and conventional composite cores using various luting agents and bonding approaches. Materials and Methods:
Marwa J. Muhammad , Alaa E. Dawood, David J. Manton   +2 more
doaj   +1 more source

Multiple finances, margins of foreign direct investment and aggregate industry productivity [PDF]

Financial Theory and Practice, 2012
Based on a heterogeneous firm set-up, we model firms’ access to the internal capital market, bank finance as well as bond finance and investigate how firms’ adjustment among multiple sources of finance affects their performance in foreign direct ...
Jiarui Zhang, Lei Hou
doaj  

Islamic Finance and the Theory of Capital Structure [PDF]

This paper empirically investigates firms using Islamic finance in Malaysia and Middle East countries. The comparative analysis of Islamic finance and non-Islamic finance users resulted in three major implications.
Nagano, Mamoru
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source