Results 61 to 70 of about 2,540,051 (294)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Frost-salt Testing Non-air Entrained High-Performance Fly-ash Concrete. Part I: Relations Liquid uptake - Internal Cracking – Scaling

Nordic Concrete Research
The surface scaling of low CO2-emission High Performance Concretes (HPC) was studied in freeze/thaw performance tests with a 3 mm layer of 3% NaCl on the surface to investigate whether such concretes can be made frost durable without air entrainment ...
Asadi Iman, Skjølsvold Ola, Kanstad Terje, Jacobsen Stefan   +3 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Influência do emprego de polímeros superabsorventes nas propriedades de materiais à base de cimento portland [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-graduação em Engenharia Civil, Florianópolis, 2009A retração autógena é um problema que atinge materiais de baixa relação a/c e alto teor de finos, como ...
Kumm, Talita Campos
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The impact of various curing methods on the curing process of polymer-fiber composites analyzed using analytical approach

Results in Engineering
Ti/Gf/Cf represents a novel form of hybrid fiber metal laminates (HFMLs) that successfully blend the benefits of titanium alloy, glass fiber reinforced plastic (GFRP), and carbon fiber reinforced plastic (CFRP). These materials have garnered attention in
Mohammadmahdi Negaresh, Hossein Nazockdast, Ali Asghar Katbab   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

THE INFLUENCE OF ENVIRONMENTAL FACTORS AND CURING PERIOD TOWARD THE PERFORMANCE AND DURABILITY OF ASPHALT MIXTURES [PDF]

, 2007
Abstrak Tujuan dari penelitian ini adalah untuk memberikan informasi terkini mengenai pengaruh periode curing (waktu jeda antara saat sampel selesai dibuat dengan waktu pengujian) dan faktor lingkungan (suhu dan kelembaban) terhadap kinerja dan ...
Hario SETIADJI, Bagus
core   +1 more source

Influence of Super Absorbent Polymer (SAP) on Mechanical, Durability Properties, and Internal Curing Mechanism of Cement Stabilized Macadam in Desert Environment

Advances in Civil Engineering
Semi-rigid base materials in desert areas are susceptible to fast evaporation of water due to high-temperature and dry environment during construction and curing, leading to insufficient cement hydration and shrinkage cracking, thus affecting the ...
Jiachen Ma, Wenhui Zhao, Zewen He, Leilei He, Fengyin Liu, Yana Shi   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source