Results 51 to 60 of about 1,428,004 (304)
Investigation of pressurized toroidal shells [PDF]
, 1967 The effect of internal pressure and external load on thin-walled toroidal shells was investigated. The result of the analysis agreed with experimental results on a 54-inch-diameter toroidal shell subjected to both pressurization and axial ...
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Blanking by means of the finite element method [PDF]
, 1998 This paper summarizes the results of simulating the blanking process by means\ud of the Finite Element Method. Unlike most of the research in this eld, the focus is not on the blanking process itself but on the deformed shape of a product after blanking.
Bolt, P.J. +5 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
, 1996 We present numerical simulations of the dynamics of two-dimensional Josephson junction arrays to study the mechanism of mutual phase locking. We show that in the presence of an external magnetic field two mechanisms are playing a role in phase locking ...
Basler M. +5 more
core +1 more source
Internal Loading Distribution in Statically Loaded Ball Bearings Subjected to an Eccentric Thrust Load [PDF]
Mathematical Problems in Engineering, 2009 Rolling‐element bearings are simple machine elements of great utility used both in simple commercial devices as in complex engineering mechanisms. Because of being a very popular machine element, there is a lot of literature on the subject. With regard to the behavior of internal loading distribution, elastic deformations at point or line contacts, and
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Battery charge-discharge controller [PDF]
, 1969 Charge-discharge controller contains punched-tape programmer capable of programming 305 discrete steps in the battery load. The indicating instrumentation includes meters for ampere-hours, watt-hours, voltage, current, and internal temperature and ...
Ciccanti, A. D.
core +1 more source
Load case characterization for the aircraft structural design process [PDF]
, 2017 Since aircraft undergo countless ground and flight scenarios during their service life, a large volume of global load cases must be analyzed in a Global Finite Element Model (GFEM) to identify the structural load paths and internal load distributions ...
Armstrong, C. G. +6 more
core +2 more sources