Results 51 to 60 of about 361,972 (301)
Applied SciencesIn the long-term performance development of rhythmic gymnasts aged 16–17, athletes enter a high-performance training phase, marked by increased training loads and preparation for international competitions.
Katarzyna Sterkowicz-Przybycień +1 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2014 The ratchet boundaries and ratchet strains are derived for the Bree problem and an elastic perfectly plastic material with different yield stresses on-load and off-load.
Chen, Haofeng +2 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Internal load during competition.
, 2020 Internal load during competition.
Adam J. Petway (8538624) +4 more
core +1 more source
No 'free ride' for African women: A comparison of head-loading versus back-loading among Xhosa women [PDF]
, 2010 Although contrasting evidence exists in the literature as to the economy of head-loading, there is a notion that head-loading is an extremely economical method of load carriage.
Davies, Simeon E.H. +10 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Experimental and finite element study of the hydroforming bi-layered tubular components [PDF]
, 2005 The application of finite element method (FEM) in the area of metal forming and material processing has been increasing rapidly during the recent years.
Islam, Mohammad Din
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source