Results 71 to 80 of about 1,428,004 (304)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Design evolution of a low shock release nut [PDF]
, 1976 Design improvements and detailed functional analyses are reviewed to trace the development of a pyroactuated release device with segmented thread design from its intermediate design into one that reduces the levels of shock spectra generated during its ...
Gordon, W., Otth, D. H.
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Applied SciencesPerceived exertion (RPE, RPEdur) and wellness scores (Hooper) are common methods to assess the training load and readiness in football. However, in professional football, there is a lack of data concerning the application of these tools in microcycles of
Lazaros Vardakis +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Are physiological, physical, wellness and load decisive markers of starting players? A case study from a professional male soccer team [PDF]
Journal of Men's HealthThe study aim was to compare physiological, physical, accumulated wellness and load markers within a European professional soccer team between starters and non-starters.
Rafael Oliveira +5 more
doaj +1 more source
Sublattice addressing and spin-dependent motion of atoms in a double-well lattice
, 2007 We load atoms into every site of an optical lattice and selectively spin flip atoms in a sublattice consisting of every other site. These selected atoms are separated from their unselected neighbors by less than an optical wavelength.
B. Brown +9 more
core +1 more source
Thermal exchange effects on steel thixoforming processes [PDF]
, 2010 Steel thixoforging is an innovative semi-solid forming process. It allows the manufacturing of complex parts and minimises the forming load. This work aims to identify and characterise the main feature zones of a thixoforging part.
BECKER, Eric +2 more
core +6 more sources
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source