Results 61 to 70 of about 3,080,192 (282)

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Pathologist-Level Grading of Prostate Biopsies with Artificial Intelligence [PDF]

open access: yesarXiv, 2019
Background: An increasing volume of prostate biopsies and a world-wide shortage of uro-pathologists puts a strain on pathology departments. Additionally, the high intra- and inter-observer variability in grading can result in over- and undertreatment of prostate cancer.
arxiv  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Sentence Simplification Aids Protein-Protein Interaction Extraction [PDF]

open access: yesThe 3rd International Symposium on Languages in Biology and Medicine, Jeju Island, South Korea, November 8-10, 2009, 2010
Accurate systems for extracting Protein-Protein Interactions (PPIs) automatically from biomedical articles can help accelerate biomedical research. Biomedical Informatics researchers are collaborating to provide metaservices and advance the state-of-art in PPI extraction. One problem often neglected by current Natural Language Processing systems is the
arxiv  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Metal artifact reduction based on the combined prior image [PDF]

open access: yesProceedings of the 12th International Meeting on Fully Three-dimensional Image Reconstruction in Radiology and Nuclear Medicine, 2013, pp. 412-415, 2014
Metallic implants introduce severe artifacts in CT images, which degrades the image quality. It is an effective method to reduce metal artifacts by replacing the metal affected projection with the forward projection of a prior image. How to find a good prior image is the key of this class methods, and numerous algorithms have been proposed to address ...
arxiv  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Real‐world genomic landscape of colon and rectal cancer

open access: yesFEBS Open Bio, Volume 15, Issue 4, Page 674-685, April 2025.
We confirmed enrichment of RTK alterations in patients with RAS/BRAF‐wt tumors and of PI3K pathway alterations in RAS/BRAF‐altered tumors with 51 982 real‐world tissue comprehensive genomic profiling (CGP) samples in CRC. In a subset of 140 patients with both tissue and liquid results, the sensitivity of liquid for results found by tissue was 100% when
Markus Schulze   +7 more
wiley   +1 more source

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