Results 61 to 70 of about 2,929,460 (308)

Intrinsic Kinds in Internal Medicine

Philosophy of Medicine
What do we mean when we diagnose a patient with a disease? What does it mean to say that two people have the same disease? In this paper, I argue that diseases are natural kinds, using a conception of kinds derived from John Stuart Mill and Ruth ...
Ilana Raburn
doaj   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

TAURINE IN INTERNAL MEDICINE

Российский кардиологический журнал, 2011
The paper is focused on taurine role in various physiological and pathophysiological processes, its effects on free radical oxidation, taurine effectiveness in chronic heart failure (CHF), and the role of free radical oxidation in heart failure ...
E. M. Pokrovskaya, I. G. Gordeev, N. A. Volov, V. A. Kokorin   +3 more
doaj  

Progress in Internal Medicine [PDF]

, 1913
Francis W. Palfrey
openalex   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Assessment of cardiac troponin I in patients with pulmonary emboli and its relationship with right ventricular dysfunction

Journal of Mazandaran University of Medical Sciences, 2009
(Received 16 December, 2008; Accepted 27 May, 2009)AbstractBackground and purpose: Right ventricular dysfunction is common in major pulmonary embolisms. The purpose of this study was to evaluate the prevalence and diagnostic utility of cardiac troponin I
Sasan Tavana, Yunes Panahi, Nasrollah Saed Moucheshi, Fatemeh Beiraghdar, Ebrahim Naderi3Department of Internal Medicine, Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran, Shahram Ala, Rouhollah Habibey   +6 more
doaj  

Internal Medicine, to What Extent Required or Elective in the Medical Course [PDF]

, 1903
S. G. BONNEY
openalex   +1 more source

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

FEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada, Kouhei Ohtani, Pushpa Kiran Gullapalli, Kazuhiko Ishikawa   +3 more
wiley   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source