Results 71 to 80 of about 3,490,356 (314)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

TriNetX and Real-World Evidence: A Critical Review of Its Strengths, Limitations, and Bias Considerations in Clinical Research

ASIDE Internal Medicine
Introduction: The increasing utilization of real-world data platforms in medical research necessitates a comprehensive understanding of their methodological strengths and limitations.
Mahmoud Nassar, Hazem Abosheaishaa, Khaled Elfert, Azizullah Beran, Abdellatif Ismail, Mouhand Mohamed, Anoop Misra, Muhammed Amir Essibayi, David J. Altschul, Ahmed Y. Azzam   +9 more
doaj   +1 more source

Venous thromboembolism and preoperative steroid use: Analysis of the NSQIP database to evaluate risk in surgical patients [PDF]

, 2015
Background Despite several prophylactic strategies, postoperative venous thromboembolism (VTE) remains a major cause of morbidity and mortality. Therefore, the search for modifiable preoperative risk factors is crucial.
Jamali, Faek R., Haddad, Anthony G., Tamim, Hani Mohammed, Kantar, Rami S., Taher, Ali T.   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epidemiological Patterns of Diabetes Mellitus in The United States of America: An Observational Multicenter Analysis From 1990 to 2024

ASIDE Internal Medicine
Introduction: Diabetes mellitus represents a significant public health challenge, however, the current trends in its epidemiology remain incompletely characterized. This study aimed to analyze epidemiological changes and demographic patterns in diabetes
Ahmed Y Azzam, Luis Medina Mora, Mahmoud M. Morsy, Muhammed Amir Essibayi, David J. Altschul, Mahmoud Nassar   +5 more
doaj   +1 more source

Evidence-Based Guidelines for Empirical Therapy of Neutropenic Fever in Korea [PDF]

, 2011
Neutrophils play an important role in immunological function. Neutropenic patients are vulnerable to infection, and except fever is present, inflammatory reactions are scarce in many cases.
Young Goo Song, 송영구, Kim, Sung Han, Choi, Jung Hyun, Dong-Gun Lee, Wan Beom Park, Song, Young Goo, Jung-Hyun Choi, Lee, Dong Gun, Soo Young Kim, Park, Wan Beom, Kim, Chung Jong, Chung-Jong Kim, Kim, Soo Young, Sung-Han Kim   +14 more
core   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Demographic Factors of Colorectal Cancer Patients with Paralytic Ileus Among Adults in the United States: A Retrospective Study for Mortality Trends

ASIDE Internal Medicine
Background: Paralytic ileus is a serious postoperative complication among individuals with colorectal cancer (CRC). Although mortality trends for CRC and paralytic ileus have been described separately, long-term national patterns involving both ...
Waheed Qaisi, Mirna Hussein, Pakeezah Tabasum, Mohamed Wagdy, Nidal Mutawodeh, Abdallah Abdallah , Mohammed Mereb, Youssef Heikal   +7 more
doaj   +1 more source

Disparities and Trends in Polycythemia Vera–Related Mortality in U.S. Adults Aged ≥45 Years from 1999 to 2023

ASIDE Internal Medicine
Background: Polycythemia vera (PV) is a rare myeloproliferative neoplasm characterized by excessive red blood cell production, leading to increased risk of thrombosis and other complications.
Alyaa Ahmed Ibrahim, Mohamed Fawzi Hemida, Mirna Hussein, Maryam Saghir, Mohammad Rayyan Faisal, FNU Kritika, Krish Patel, Amro Ali, Eshal Saghir, Mahmoud Tablawy, Abdelrhman H. Mohamed, Amr Arafa   +11 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source