Results 131 to 140 of about 8,905 (245)
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
GETTİER SONRASI EPİSTEMOLOJİDE DESCARTES ODAKLI BİLGİ TANIMI TARTIŞMALARI
Felsefe Dünyası, 2014 E. Gettier’in “Is Justified True Belief Knowledge?”(GerekçelendirilmişDoğru İnanç Bilgi midir?) adlı küçük makalesi, felsefe tarihinin en etkili yazılarındanbirisi olmakla kalmayıp, aynı zamanda felsefenin özgün alanlarınınbaşında gelen epistemolojide de
Nebi Mehdiyev
doaj
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Externalism and knowledge: how to follow rules
Омский научный вестник: Серия "Общество. История. Современность"The aim of the paper is to show that Kripke-Wittgenstein’s rule-following paradox assumes the premise of epistemic internalism that inappropriately restricting the admissible answers about how agents can know the rules or meanings of linguistic ...
A. M. Kardash
doaj +1 more source
What normative terms mean and why it matters for ethical theory [PDF]
, 2015 This paper investigates how inquiry into normative language can improve substantive normative theorizing. First I examine two dimensions along which normative language differs: “strength” and “subjectivity.” Next I show how greater sensitivity to these ...
Silk, Alex
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Historiographies of science and labor: From past perspectives to future possibilities. [PDF]
Hist Sci, 2023 Roberts L, Rockman S, Hui A.
europepmc +1 more source