Results 111 to 120 of about 2,748,947 (309)

How to Supplement Mentalist Evidentialism: What Are the Fundamental Epistemological Principles? [PDF]

Theoria, 2022
Berghofer P.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Internal to what? A critique of the distinction between internal and external reasons for action [PDF]

, 2000
The distinction between internalism and externalism can be interpreted in different ways, which must be kept clearly distinct. The distinction between internal and external reasons for action, proposed by Bernard Williams (1980), can be interpreted as ...
Mordacci, Roberto
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Wittgenstein on Knowledge (1949-1951) [PDF]

, 2003
In this paper, I want to characterize Wittgenstein"s epistemology, namely his contextualism, presented in his notes published under the title On Certainty.
Bouchard, Yves
core  

Do Moral Beliefs Motivate Action? [PDF]

Ethical Theory Moral Pract, 2023
Díaz R.
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Place Goes Wrong in Treating Mind-brain Relationship

Journal of Philosophical Investigations, 2015
U. T. Place claims that philosophical problems concerning the true nature of mind-brain relationship disappears or is settled adhering to materialism, especially type identity theory of mind. He takes above claim as a reasonable scientific hypothesis.
Mahdi Soleimani Khourmouji
doaj  

Justification [PDF]

, 2018
In the most general sense, the term“justification” refers to the act of providing reasons for the validity, legitimacy, and defensibility of (1) an action, (2) a belief, and/or (3) a social arrangement.
Susen, S.
core