Hierarchy Theory of Evolution and the Extended Evolutionary Synthesis: Some Epistemic Bridges, Some Conceptual Rifts [PDF]
, 2018 Contemporary evolutionary biology comprises a plural landscape of multiple co-existent conceptual frameworks and strenuous voices that disagree on the nature and scope of evolutionary theory.
A Etxeberria +113 more
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HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Metaethics in context of engineering ethical and moral systems [PDF]
, 2016 It is not clear to what the projects of creating an artificial intelligence (AI) that does ethics, is moral, or makes moral judgments amounts. In this paper we discuss some of the extant metaethical theories and debates in moral philosophy by which such ...
Frank, Lily, Klincewicz, Michal
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Resultant moral luck and the scope of moral responsibility. [PDF]
Philos Stud, 2023 Rolffs M.
europepmc +1 more source
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
Should We Swap Internal Foundations for Virtues?
Crítica, 2019 Internalist foundationalism was popular through much of the history of Western epistemology, but has been subjected to intense critical scrutiny in the last century.
Ram Neta
doaj +1 more source
Scratching the structure of moral agency: insights from philosophy applied to neuroscience. [PDF]
Front Neurosci, 2023 Castro-Toledo FJ +2 more
europepmc +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Minimalist Meaning, Internalist Interpretation
Biolinguistics, 2008 This article offers a conception of semantics, and of what makes the human language faculty distinctive, based on five theses: Meanings are instructions to build concepts; concatenation calls for conjunction of monadic concepts; grammatical relations ...
Paul M. Pietroski
doaj +1 more source
The Real Trouble for Armchair Arguments Against Phenomenal Externalism [PDF]
, 2014 I criticize some armchair arguments against phenomenal externalism due to Block, Hawthorne, Kriegel, Levine, Shoemaker and others.
Pautz, Adam
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