Results 81 to 90 of about 2,748,947 (309)

Lessons and new directions for extended cognition from social and personality psychology [PDF]

open access: yes, 2017
This paper aims to expand the range of empirical work relevant to the extended cognition debates. First, I trace the historical development of the person-situation debate in social and personality psychology and the extended
Skorburg, Joshua August
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Against Smallism And Localism

open access: yesStudies in Logic, Grammar and Rhetoric, 2015
The question whether cognition ever extends beyond the head is widely considered to be an empirical issue. And yet, all the evidence amassed in recent years has not sufficed to settle the debate.
de Oliveira Guilherme Sanches   +1 more
doaj   +1 more source

Epistemology and Ontology of the Quality. An Introduction to the Enactive Approach to Qualitative Ontology [PDF]

open access: yes, 2016
The concept of quality points at a significant philosophical problem. The issue of the ontological status of the qualities of experience and reality leads us to discuss the issues of naturalism and reductionism in philosophy of mind.
Pace Giannotta, Andrea
core   +1 more source

Moral disengagement and the motivational gap in climate change [PDF]

open access: yes, 2019
Although climate change jeopardizes the fundamental human rights of current as well as future people, current actions and ambitions to tackle it are inadequate.
Diependaele, Lisa   +2 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Necessity and Liability: On an Honour-Based Justification for Defensive Harming [PDF]

open access: yes, 2016
This paper considers whether victims can justify what appears to be unnecessary defensive harming by reference to an honour-based justification. I argue that such an account faces serious problems: the honour-based justification cannot permit, first ...
Bowen, Joseph
core   +1 more source

Reasons and Theories of Sensory Affect [PDF]

open access: yes, 2018
Some sensory experiences are pleasant, some unpleasant. This is a truism. But understanding what makes these experiences pleasant and unpleasant is not an easy job. Various difficulties and puzzles arise as soon as we start theorizing.
Aydede, Murat, Fulkerson, Matthew
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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