Results 81 to 90 of about 3,311 (254)

Internalism, (Super)fragile Reasons, and the Conditional Fallacy [PDF]

open access: yes, 2003
David Sobel (2001) objects to Bernard Williams's internalism, the view that an agent has a reason to perform an action only if she has some motive that will be served by performing that action.
Robertson, Teresa
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Perspectives on Natural Philosophy

open access: yesPhilosophies, 2018
This paper presents a viewpoint on natural philosophy focusing on the organization of substance, as well as its changes as invited by the Second Law of thermodynamics.
Stanley N. Salthe
doaj   +1 more source

Internalism Re-explained

open access: yes, 2017
According to ‘internalism’, what it is rational for me to think at a given time depends purely on the internal mental states and events that are present in my mind at that time. Intuitively, internalism is compelling.
Ralph Wedgwood
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Against Smallism And Localism

open access: yesStudies in Logic, Grammar and Rhetoric, 2015
The question whether cognition ever extends beyond the head is widely considered to be an empirical issue. And yet, all the evidence amassed in recent years has not sufficed to settle the debate.
de Oliveira Guilherme Sanches   +1 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Is De Dicto motivation manifestly a no-go?

open access: yesRivista Internazionale di Filosofia e Psicologia
The aim of this paper is to challenge Michael Smith’s influential “fetishism charge” against motivational externalism – the view that moral judgments motivate only in the presence of a distinct conative state.
Irene Bosco
doaj   +1 more source

Problem indywiduacji i internalizacji działań (The Problem of Action Individuation and Internalization) [PDF]

open access: yesAnaliza i Egzystencja, 2010
One of the striking features of Davidson’s account of action individuation is the internalization of actions to the domain of bodily movements. I reconstruct Davidson’s arguments for that claim as applying mainly against naïve externalism (according to ...
Katarzyna Paprzycka
doaj  

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