Results 61 to 70 of about 2,748,947 (309)
Some Problems for Biolinguistics
Biolinguistics, 2014 Biolinguistics will have to face and resolve several problems before it can achieve a pivotal position in the human sciences. Its relationship to the Minimalist Program is ambiguous, creating doubts as to whether it is a genuine subdiscipline or merely ...
Derek Bickerton
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Du quotidien au droit ou la compréhension du droit par l’étude du quotidien des juristes
Cahiers Jean Moulin, 2019 Everyday life is an unusual matter for the legal research; indeed, it is wrongly often relegated to the fields of sociology or political science. Yet, the study of the everyday law can nevertheless reveal valuable lessons for the jurist, provided of ...
Michael Koskas
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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ReligionsThe semantic internalist–externalist debate is one of the central themes in contemporary philosophy. The present paper aims to explore the dispute between Śāntarakṣita and his opponents over the meaning of words (śabdārtha) in the śabdārthaparīkṣā ...
Long Yin Sin
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
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Luka eksplanacyjna a pojęcia własności fenomenalnych stanowisko Josepha Levine’a ( Explanatory gap and the concept of phenomenal properties: Joseph Levine’s view) [PDF]
Analiza i Egzystencja, 2012 The explanatory gap problem arises in the context of the mind-body relation, and especially the phenomenal concepts-physical concepts relation. It is posed as a question about the method which is appropriate for the reduction of consciousness to physical
Adriana Schetz
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Освітній дискурс, 2019 The article examines the dominant paradigm and current research state of the theoretical and practical dimension of cooperative behavior based on the notion of “collective intentionality” scrutinized within the framework of analytic social philosophy ...
Frol Revin
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
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