Results 91 to 100 of about 2,748,947 (309)
Problem indywiduacji i internalizacji działań (The Problem of Action Individuation and Internalization) [PDF]
Analiza i Egzystencja, 2010 One of the striking features of Davidson’s account of action individuation is the internalization of actions to the domain of bodily movements. I reconstruct Davidson’s arguments for that claim as applying mainly against naïve externalism (according to ...
Katarzyna Paprzycka
doaj
RATIONALITY: NORMAL MENTAL FUNCTIONING OR PSYCHOLOGICAL COHERENCE?
Problemos, 2012 A version of the rationalist internalist argument, employing a pro tanto reading of the term “normative reason”, is often criticized due to its conception of rationality.
Ieva Vasilionytė
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Rule-Following Made Easy [PDF]
, 2003 I wish to argue that the problem of rule-following rests on semantic internalism and that semantic externalism makes the problem evaporate. Given that the rule-following problem is a version of the general problem that the reference of an intentional ...
Bernecker, Sven
core
, 2010 The internalism/externalism debate is of interest in epistemology since it addresses one of the most fundamental questions in the discipline: what is the basic nature of knowledge and epistemic justification?
Madison, Brent J C
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Is De Dicto motivation manifestly a no-go?
Rivista Internazionale di Filosofia e PsicologiaThe aim of this paper is to challenge Michael Smith’s influential “fetishism charge” against motivational externalism – the view that moral judgments motivate only in the presence of a distinct conative state.
Irene Bosco
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FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Logos I - Philosophy and the Nature of Morality: The Abolition of Man, C.S. Lewis [PDF]
, 2018 C.S. Lewis’ objective stance on ethics is argued to be superior to the moral sentimentalism of David Hume, because if there is not agreement on what constitutes moral action, then there is no basis for argument over the existence of moral ...
Steiner, Lucie
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