Results 61 to 70 of about 8,919 (253)

Preservationism in the Epistemology of Memory [PDF]

, 2016
Preservationism states that memory preserves the justification of the beliefs it preserves. More precisely: if S formed a justified belief that p at t1 and retains in memory a belief that p until t2, then S's belief that p is prima facie justified via ...
Frise, Matthew
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Epistemic internalism [PDF]

, 2010
The internalism/externalism debate is of interest in epistemology since it addresses one of the most fundamental questions in the discipline: what is the basic nature of knowledge and epistemic justification?
Madison, Brent J C
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Epistemic Luck and the Extended Mind [PDF]

, 2019
Contemporary debates about epistemic luck and its relation to knowledge have traditionally proceeded against a tacit background commitment to cognitive internalism, the thesis that cognitive processes play out inside the head. In particular, safety-based
Carter, J. Adam
core   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Hierarchy Theory of Evolution and the Extended Evolutionary Synthesis: Some Epistemic Bridges, Some Conceptual Rifts [PDF]

, 2018
Contemporary evolutionary biology comprises a plural landscape of multiple co-existent conceptual frameworks and strenuous voices that disagree on the nature and scope of evolutionary theory.
A Etxeberria, A Fuentes, A Parravicini, A Vianello, A Wagner, AC Love, Alejandro Fábregas-Tejeda, AV Badyaev, B Bocxlaer Van, BS Lieberman, BS Lieberman, D Noble, D Sepkoski, D Sloan-Wilson, DD Turner, DJ Depew, DJ Futuyma, DJ Nicholson, DL Hull, DM Walsh, DR Piperno, DT Campbell, E Danchin, E Jablonka, E Jablonka, E Jablonka, E Mayr, E Mayr, E Serrelli, E Szathmáry, EI Svensson, ES Vrba, ES Vrba, ES Vrba, F Suman, F Vergara-Silva, FJ Odling-Smee, FJ Odling-Smee, Francisco Vergara-Silva, GB Müller, GB Müller, GG Simpson, GJ Cooper, GP Wagner, GP Wagner, I Tëmkin, I Tëmkin, I Tëmkin, J Beatty, J Griesemer, J Griesemer, J Odling-Smee, J Odling-Smee, JJ Welch, JW Pepper, K Laland, K Laland, K Stotz, KN Laland, KN Laland, KN Laland, KN Laland, M Bertolaso, M Blute, M Lynch, M Martínez, M Nei, M Pavličev, M Pigliucci, M Pigliucci, MD Laubichler, MJ Denton, MW Kirschner, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, N Eldredge, P Alberch, P Bateson, P Godfrey-Smith, PJ Bowler, R Amundson, R Amundson, R Riedl, R Sansom, RG Delisle, RG Winther, S Caianiello, S Okasha, S Okasha, S Oyama, S Sultan, SF Gilbert, SJ Gould, SJ Gould, T Ingold, T Ingold, T Pievani, T Pievani, T Pievani, T Pievani, TA Grantham, TS Kemp, TS Kemp, U Dieckmann, W Miller III, W Miller III, WB Provine, WD Allmon, WE Reif   +113 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Perspectives on Natural Philosophy

Philosophies, 2018
This paper presents a viewpoint on natural philosophy focusing on the organization of substance, as well as its changes as invited by the Second Law of thermodynamics.
Stanley N. Salthe
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source