Results 111 to 120 of about 621,017 (390)

課程研究：從再概念化到後再概念化及國際化 Curriculum Studies: From Reconceptualization to Post-reconceptualization and Internationalization

臺灣教育社會學研究, 2008
早期的課程研究受到時代氛圍的影響，致力於合理性課程編製程序的解析。但是1960年代開始，某些課程學者開始從人文主義的立場出發，對傳統課程研究提出質疑。1970年代，挑戰傳統課程研究的個別力量開始匯聚成一股集體的力量，強調以嶄新思維來構思課程經驗的再概念化運動就此展開。再概念化論者認為，課程研究不應戮力於課程的發展，而應著重於課程的理解，而且他們主張將課程視為一種「文本」，因此，隨著援引領域的不同，便形成各種不同的課程文本觀。在進入1980年代之後，再概念化運動受到新興思潮影響，其力量進一步擴散 ...
鍾鴻銘 Horng-Ming Jong
doaj  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Actin cytoskeleton-dependent regulation of corticotropin-releasing factor receptor heteromers [PDF]

, 2017
Stress responses are highly nuanced and variable, but how this diversity is achieved by modulating receptor function is largely unknown. Corticotropin-releasing factor receptors (CRFRs), class B G protein–coupled receptors, are pivotal in mediating ...
Bhargava, Aditi, Burlingame, Alma, Chand, Shreya, Grammatopoulos, Dimitris K., Hasdemir, Burcu, Mahajan, Shilpi, Oses-Prieto, Juan, Woolley, Michael J.   +7 more
core   +1 more source

Internal normality and internal compactness

Topology and its Applications, 2008
AbstractThis text contains an example which presents a way to modify any Dowker space to get a normal space X such that X×[0,1] is not κ-normal, and a theorem implying the existence of a non-Tychonoff space which is internally compact in a larger regular space. It gives answers to several questions by Arhangel'skii [A.V.
David Chodounský, Eva Murtinová
openaire   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

CORPORATE INTERNALIZATION OF SUSTAINABILITY REQUIREMENTS [PDF]

Sustainability has become the boiling point of theoretical business discussions. At first it was only a concept everybody was talking about but no one knew how it should be materialized.
Ransburg, Beatrix
core   +1 more source

Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner [PDF]

, 2016
Cannabinoid receptor interacting protein 1a (CRIP1a) is a CB1 receptor (CB1R) distal C-terminus-associated protein that modulates CB1R signaling via G proteins, and CB1R down-regulation but not desensitization (Blume et al.
Bass, Caroline E., Blumes, Lawrence C, Chen, Rong, Howlett, Allyn C., Leone-Kabler, Sandra, Luessen, Deborah J., Lyons, Erica, Marrs, Glenn S., Selley, Dana E.   +8 more
core   +2 more sources

Is International Law International?

, 2017
Is International Law International? takes the reader on a sweeping tour of the international legal academy to reveal some of the patterns of difference, dominance, and disruption that belie international law’s claim to universality. Both revealing and challenging, confronting and engaging, this book is a must-read for any international lawyer ...
Anthea Roberts, Martti Koskenniemi
openaire   +2 more sources

Daratumumab induces CD38 internalization and impairs myeloma cell adhesion

OncoImmunology, 2018
Daratumumab (Dara), a human immunoglobulin G1 kappa (IgG1κ) monoclonal anti-CD38 antibody, has been approved by the U.S. Food and Drug Administration for the treatment of relapsed multiple myeloma (MM) as a single agent as well as in combination with ...
Jayeeta Ghose, Domenico Viola, Cesar Terrazas, Enrico Caserta, Estelle Troadec, Jihane Khalife, Emine Gulsen Gunes, James Sanchez, Tinisha McDonald, Guido Marcucci, Balveen Kaur, Michael Rosenzweig, Jonathan Keats, Steven Rosen, Amrita Krishnan, Abhay R Satoskar, Craig C Hofmeister, Flavia Pichiorri   +17 more
doaj   +1 more source