Results 91 to 100 of about 157,480 (269)
On Minimal Absorption Index for an n-Dimensional Simplex
Моделирование и анализ информационных систем, 2018 Let \(n\in{\mathbb N}\) and let \(Q_n\) be the unit cube \([0,1]^n\). For a nondegenerate simplex \(S\subset{\mathbb R}^n\), by \(\sigma S\) denote the homothetic copy of \(S\) with center of homothety in the center of gravity of \(S\) and ratio of ...
Mikhail V. Nevskii, Alexey Y. Ukhalov
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Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
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On Some Problem for a Simplex and a Cube in Rⁿ
Моделирование и анализ информационных систем, 2013 Let S be a nondegenerate simplex in Rⁿ. Denote by α(S) the minimal σ > 0 such that the unit cube Qn:= [0, 1]ⁿ is contained in a translate of σS. In the case α(S) ≠ 1 the translate of α(S)S containing Qn is a homothetic copy of S with the homothety ...
M. V. Nevskii
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Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
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On Some Results in the Geometry of Convex Bodies and their Applications
Моделирование и анализ информационных систем, 2015 We give a survey of some results in the geometry of convex bodies and their applications.
M. V. Nevskii
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
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Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
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Monatshefte für Mathematik, 1984 Triangular interpolation problems (problems with biorthogonal polynomial sequence) are studied. Convergence of the corresponding interpolation series in investigated. It is shown that the interpolation polynomials form a basis in appropriate nuclear Fréchet spaces.
openaire +2 more sources