Results 71 to 80 of about 182,993 (316)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

open access: yesInternational Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri   +2 more
wiley   +1 more source

Comparative Study of the Dynamics of Cosmic Rays for the Pakistan and China Atmospheric Regions

open access: yesJournal of Mathematical and Fundamental Sciences, 2020
This paper presents an analysis of cosmic ray intensity in Pakistan air space using spatial interpolation, comparing it with Chinese cosmic ray records from 1984 to 1993.
Faisal Nawaz   +4 more
doaj   +1 more source

Rewriting Interpolants

open access: yesElectronic Notes in Theoretical Computer Science, 2008
AbstractWe give a method of constructing an interpolant for linear equality, and inequality constraints over the rational numbers. Our method is based on efficient rewriting techniques, and does not require the use of combination methods. The interpolant is constructed in such a way that it reflects the structure of the rewrite proof.
Christopher S. Lynch, Yuefeng Tang
openaire   +2 more sources

Material interpolations

open access: yesJournal of Social Science Education, 2022
JSSE - Journal of Social Science Education, Bd. 21 Nr. 1 (2022)
openaire   +4 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Computing knots by quadratic and cubic polynomial curves

open access: yesComputational Visual Media, 2020
A new method is presented to determine parameter values (knot) for data points for curve and surface generation. With four adjacent data points, a quadratic polynomial curve can be determined uniquely if the four points form a convex polygon.
Fan Zhang   +3 more
doaj   +1 more source

A Novel Interpolation-SVT Approach for Recovering Missing Low-Rank Air Quality Data

open access: yesIEEE Access, 2020
With increasing public demands for timely and accurate air pollution reporting, more air quality monitoring stations have been deployed by the governments in urban metropolises to increase the coverage of urban air pollution monitoring.
Yangwen Yu   +3 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

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