Results 111 to 120 of about 424,704 (329)
Do Users Benefit From Interpretable Vision? A User Study, Baseline, And Dataset [PDF]
, 2022 Leon Sixt +4 more
openalex +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Weakly supervised learning in thymoma histopathology classification: an interpretable approach
Frontiers in MedicineIntroductionThymoma classification is challenging due to its diverse morphology. Accurate classification is crucial for diagnosis, but current methods often struggle with complex tumor subtypes.
Chunbao Wang +14 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
An Interpretable Transformer Model for Operational Flare Forecasting
Proceedings of the International Florida Artificial Intelligence Research Society ConferenceInterpretable machine learning tools including LIME (Local Interpretable Model-agnostic Explanations) and ALE (Accumulated Local Effects) are incorporated into a transformer-based deep learning model, named SolarFlareNet, to interpret the predictions ...
Yasser Abduallah +2 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
IRGL-RRI: interpretable graph representation learning for plant RNA–RNA interaction discovery
Frontiers in Plant SciencePlant RNAs are crucial for plant gene expression and protein synthesis. They modulate the spatial structure of themselves and associated molecules, thereby influencing transcription, translation and gene expression regulation.
Qingquan Liao +6 more
doaj +1 more source