Results 121 to 130 of about 157,570 (268)

Interpretable graph-based models on multimodal biomedical data integration: a technical review and benchmarking. [PDF]

Nat Commun
Sadeghi A, Hajati F, Argha A, H Lovell N, Yang M, Alinejad-Rokny H.   +5 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Developing an Interpretable Machine Learning Model for Early Prediction of Cardiovascular Involvement in Systemic Lupus Erythematosus

Journal of Inflammation Research
Zixian Deng,1 Huadong Liu,1 Feng Chen,2 Qiyun Liu,1 Xiaoyu Wang,3 Caiping Wang,1 Chuangye Lyu,1 Jianghua Li,1 Tangzhiming Li1,4 1Department of Cardiology, Shenzhen People’s Hospital (The First Affiliated Hospital, Southern University of Science and ...
Deng Z, Liu H, Chen F, Liu Q, Wang X, Wang C, Lyu C, Li J, Li T   +8 more
doaj  

Assessment of the Technical Interpretability of Prehospital ECGs Performed by Medical and Nonmedical Teams in a French Emergency Medical System: A Descriptive Pilot Study. [PDF]

Emerg Med Int
Duval D, Douillet D, Savary D.
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

FUSION-AD: interpretable AI framework for risk assessment and subgroup discovery in Alzheimer's disease. [PDF]

Front Neuroinform
Iqbal A, Arif S, Husnain G, Ayouni S.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Artificial intelligence approaches in biological age prediction: current status and challenges. [PDF]

Br J Biomed Sci
Wang G, Ding P, Li Z, Tang Q, Tu L, Jiang T, Zhang L, Su B, Xu J, An H.   +9 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source