Results 141 to 150 of about 1,818,152 (349)
The consultation as an interpretive dialogue about the child's health needs [PDF]
, 2011 Kirsten Lykke +2 more
openalex +1 more source
How Teachers Interpret And Implement Independent Curriculum: Lesson Learnt From The Field
, 2023 Ayu Anggraeni, Henny Soepriyanti
openalex +2 more sources
Online Product Feature Recommendations with Interpretable Machine Learning [PDF]
, 2021 Mingming Guo +4 more
openalex +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
variancePartition: interpreting drivers of variation in complex gene expression studies
, 2016 Gabriel E. Hoffman, Eric E. Schadt
openalex +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Unveiling interpretable development-specific gene signatures in the developing human prefrontal cortex with ICGS [PDF]
, 2022 Meng Huang, Xiucai Ye, Tetsuya Sakurai
openalex +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source