Results 71 to 80 of about 295,552 (260)

CDPNet: a deformable ProtoPNet for interpretable wheat leaf disease identification

Frontiers in Plant Science
IntroductionAccurate identification of wheat leaf diseases is crucial for food security, but existing prototype-based computer vision models struggle with the scattered nature of lesions in field conditions and lack interpretability.
Jinyu Zeng, Bingjing Jia, Chenguang Song, Hua Ge, Lei Shi, Bo Kang   +5 more
doaj   +1 more source

Increasing stability and interpretability of gene expression signatures

, 2010
Motivation : Molecular signatures for diagnosis or prognosis estimated from large-scale gene expression data often lack robustness and stability, rendering their biological interpretation challenging.
Haury, Anne-Claire, Jacob, Laurent, Vert, Jean-Philippe   +2 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Deep Learning for Time-Series Forecasting With Exogenous Variables in Energy Consumption: A Performance and Interpretability Analysis

IEEE Access
The rise of decentralized energy sources and renewables demands advanced grid planning, with short-term load forecasting (STLF) playing a crucial role.
Ava Mohammadi, Gonzalo Napoles, Yamisleydi Salgueiro   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Graph-Based Radiomics Feature Extraction From 2D Retina Images

IEEE Access
Medical image analysis offers valuable visual support for clinical decision-making, yet the incorporation of quantitative data is essential for deeper diagnostic insight. The radiomics approach addresses this need by combining quantitative image analysis
Ofelio Jorreia, Nuno Goncalves, Rui Cortesao   +2 more
doaj   +1 more source

Reconstruction of separably categorical metric structures

, 2014
We extend Ahlbrandt and Ziegler's reconstruction results to the metric setting: we show that separably categorical metric structures are determined, up to bi-interpretability, by their automorphism ...
Kaïchouh, Adriane, Yaacov, Itaï Ben
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source