Results 21 to 30 of about 596,231 (252)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Development and validation of a leukemia prognostic model through single-cell RNA sequencing and machine learning approaches

Discover Oncology
Background Leukemia prognosis varies significantly among patients, highlighting the need for accurate prediction tools. Emerging evidence suggests that the immune microenvironment plays a crucial role in leukemia progression and treatment response ...
Doujia Chen, Jie Yang, Mengting Wang, Tianye Jian   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Replicating human characteristics: A promising animal model of central fatigue

Brain Research Bulletin
Central fatigue is a common pathological state characterized by psychological loss of drive, lack of appetite, drowsiness, and decreased psychic alertness.
Yifei Zhang, Zehan Zhang, Qingqian Yu, Bijuan Lan, Qinghuan Shi, Ruting Li, Ziheng Jiao, Weiyue Zhang, Feng Li   +8 more
doaj   +1 more source

Road Safety Audit for the Intersection of US 59 and IA 9 in Osceola County, Iowa Final Report, March 2012 [PDF]

, 2012
The Iowa Department of Transportation (DOT) requested a road safety audit (RSA) of the US 59/IA 9 intersection in northwestern Iowa, just south of the Minnesota border, to assess intersection environmental issues and crash history and recommend ...

core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Evaluation of reports received on a digital platform for monitoring and self-care of individuals facing the COVID-19 pandemic in Brazil: Contributions to public health

Clinical Epidemiology and Global Health
Objectives: To evaluate the contribution of the digital platform “Meu Diário de Quarentena (MDQ)'' or My Quarantine Diary concerning the monitoring and self-care of individuals with COVID-19 in Brazil.
Luiz Ricardo Albano dos Santos, Luana Michelly Aparecida Costa dos Santos, Guilherme José Aguilar, Wilbert Dener Lemos Costa, Dantony de Castro Barros Donato, Valdes Roberto Bollela, Alan Maicon de Oliveira   +6 more
doaj   +1 more source

Sustainable leadership pre- and within the 21st century [PDF]

Environmental Economics, 2017
This paper reviews literature on sustainable leadership pre- and within the 21st century, using the following nuances: (1) selected dynamics attributable to socio-demographics, (2) implications and barriers that skew gender and leadership bias, and (3 ...
Bloodless Dzwairo, Ntombenhle Nombela, Manoshni Perumal   +2 more
doaj   +1 more source

Embodying the Fat/Trans Intersection [PDF]

, 2019
This chapter explores how the fat/trans intersection is embodied with the aim of highlighting some of the assumptions underpinning existing approaches to gender within Fat Studies, and more broadly to ask what the role of fat is in producing gendered ...
White, F.R.
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source