Results 41 to 50 of about 615,758 (305)

Transmission of severe fever with thrombocytopenia syndrome virus from a dog to humans and a cat in a household cluster

One Health
The growing proximity and contact between companion animals and humans underscore the significant public health risk of zoonotic spillover, a core concern of the One Health framework.
Dongyu Ma, Wangjun Li, Tao Liao, Yongqing Song, Jun Ma, Hecheng Lu, Hanbing Liu, Wei Liu, Qi Zhang, Tingting Hu, Yaping Zhu, Wei Chen   +11 more
doaj   +1 more source

Prediction of Frequency for Simulation of Asphalt Mix Fatigue Tests Using MARS and ANN

The Scientific World Journal, 2014
Fatigue life of asphalt mixes in laboratory tests is commonly determined by applying a sinusoidal or haversine waveform with specific frequency. The pavement structure and loading conditions affect the shape and the frequency of tensile response pulses ...
Ali Reza Ghanizadeh, Mansour Fakhri
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Development and validation of a leukemia prognostic model through single-cell RNA sequencing and machine learning approaches

Discover Oncology
Background Leukemia prognosis varies significantly among patients, highlighting the need for accurate prediction tools. Emerging evidence suggests that the immune microenvironment plays a crucial role in leukemia progression and treatment response ...
Doujia Chen, Jie Yang, Mengting Wang, Tianye Jian   +3 more
doaj   +1 more source

Modelling the Effect of Information and Communication Technology on Activity-Based Travels, Case Study: Tehran

Transport and Telecommunication, 2019
Information and communication technology (ICT) has revolutionized almost all aspects of human life. Thus, examining the effect of this technology on social problems such as traffic congestion, environmental pollution, urban design, land use etc.
Edrisi Ali, Ashkrof Peyman, Ganjipour Houmaan   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Decoding TGR5: A comprehensive review of its impact on cerebral diseases

Pharmacological Research
Currently, unraveling the enigmatic realm of drug targets for cerebral disorders poses a formidable challenge. Takeda G protein-coupled receptor 5 (TGR5), also known as G protein-coupled bile acid receptor 1, is a specific bile acid receptor.
Zehan Zhang, Yifei Zhang, Hongye Peng, Qingqian Yu, Xiangdong Kang, Ying Liu, Yuxiao Zheng, Fafeng Cheng, Xueqian Wang, Feng Li   +9 more
doaj   +1 more source

Road Safety Audit for the Intersection of US 59 and IA 9 in Osceola County, Iowa Final Report, March 2012 [PDF]

, 2012
The Iowa Department of Transportation (DOT) requested a road safety audit (RSA) of the US 59/IA 9 intersection in northwestern Iowa, just south of the Minnesota border, to assess intersection environmental issues and crash history and recommend ...

core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Replicating human characteristics: A promising animal model of central fatigue

Brain Research Bulletin
Central fatigue is a common pathological state characterized by psychological loss of drive, lack of appetite, drowsiness, and decreased psychic alertness.
Yifei Zhang, Zehan Zhang, Qingqian Yu, Bijuan Lan, Qinghuan Shi, Ruting Li, Ziheng Jiao, Weiyue Zhang, Feng Li   +8 more
doaj   +1 more source