Results 51 to 60 of about 615,758 (305)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Clinical Epidemiology and Global HealthObjectives: To evaluate the contribution of the digital platform “Meu Diário de Quarentena (MDQ)'' or My Quarantine Diary concerning the monitoring and self-care of individuals with COVID-19 in Brazil.
Luiz Ricardo Albano dos Santos +6 more
doaj +1 more source
Sustainable leadership pre- and within the 21st century [PDF]
Environmental Economics, 2017 This paper reviews literature on sustainable leadership pre- and within the 21st century, using the following nuances: (1) selected dynamics attributable to socio-demographics, (2) implications and barriers that skew gender and leadership bias, and (3 ...
Bloodless Dzwairo +2 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The Optimal Allocation of the Library Space to Books Using Cuckoo Algorithm
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2015 Purpose: The goal of this research is to describe how we can arrange the books in the shelves such that leads to minimization of the movement of the clients in the library and reduction of restrictions on the number and volume of each type of book ...
houshmand moradveisi +1 more
doaj
Frontiers in Public HealthThe accelerating demographic transition has brought the mental health of older adults to the forefront of public health concerns. Middle-aged and older adults (aged 50–69 years), often described as the “young-old,” are particularly vulnerable to early ...
Han Zhang, Siqi Zhu
doaj +1 more source
The intersection of retracts of A∗
Theoretical Computer Science, 2000 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Intersecting and Cross-Intersecting Families of Labeled Sets [PDF]
The Electronic Journal of Combinatorics, 2008 A family ${\cal A}$ of sets is said to be intersecting if any two sets in ${\cal A}$ intersect. Families ${\cal A}_1, ..., {\cal A}_p$ are said to be cross-intersecting if, for any $i, j \in \{1, ..., p\}$ such that $i \neq j$, any set in ${\cal A}_i$ intersects any set in ${\cal A}_j$. For ${\bf k} = (k_1, ..., k_n) \in {\Bbb N}^n$, $2 \leq k_1 \leq ..
openaire +4 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Intersectional Strategies for Targeting Amacrine and Ganglion Cell Types in the Mouse Retina
Frontiers in Neural Circuits, 2018 The mammalian retina harbors over 100 different cell types. To understand how retinal circuits work, it is essential to systematically access each type. A widely used approach for achieving targeted transgene expression exploits promoter-driven Cre lines.
Andrew Jo +7 more
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