Results 61 to 70 of about 596,231 (252)

Lacticaseibacillus paracasei JS-3 Isolated from “Jiangshui” Ameliorates Hyperuricemia by Regulating Gut Microbiota and iTS Metabolism

Foods
Background: A diet high in purines can impair the function of the gut microbiota and disrupt purine metabolism, which is closely associated with the onset of hyperuricemia.
Jiahui Wu, Lvbu Aga, Leimengyuan Tang, Houxier Li, Nan Wang, Li Yang, Nan Zhang, Xiang Wang, Xueyong Wang   +8 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The effect and mechanism of freeze-dried powder of Poecilobdella manillensis on improving inflammatory injury of rat glomerular mesangial cells through TXNIP / NLRP3 pathway

Heliyon
s: Objective: Diabetic kidney disease (DKD) is a common complication of diabetes mellitus. The pathophysiological changes in platelet function and the hypercoagulable state associated with DKD are closely linked to inflammatory processes.
Xi Sun, Maiheliya Mijiti, Chuyin Huang, Shanshan Mei, Kexin Fang, Yaojun Yang   +5 more
doaj   +1 more source

Analysis of delay due to military motorized column circulation at intersections

Vojnotehnički Glasnik, 1997
During the circulation of a military motorized column on the roads the delay at intersections makes significant share of the total travel time. The paper presents the analysis of military motorized column circulation at intersections from delay aspect ...
Milorad Opsenica
doaj   +1 more source

Session Types = Intersection Types + Union Types [PDF]

, 2011
We propose a semantically grounded theory of session types which relies on intersection and union types. We argue that intersection and union types are natural candidates for modeling branching points in session types and we show that the resulting ...
Luca Padovani, Padovani, Luca
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Optimization of signal control at ramp adjacent intersections based on A2C

Shenzhen Daxue xuebao. Ligong ban
The operational efficiency of urban expressways significantly impacts citywide transportation flow. During morning and evening rush hours, the limited capacity of feeder roads to handle high traffic volumes leads to congestion on expressway exit ramps ...
SONG Tailong, GUO Mingyang, CHEN Yifan, HE Yulong   +3 more
doaj   +1 more source

Intersection Traffic Control Based on Multi-Objective Optimization

IEEE Access, 2020
Currently, most traffic control methods at intersections rely on the control of signal lights. However, most signal lights operate in the traditional fixed timing mode, which cannot adjust the timing based on the time-varying traffic flow.
Jinbao Mou
doaj   +1 more source

Accurate Simulation of Spectroscopic Signatures of Cavity-Assisted, Conical-Intersection-Controlled Singlet Fission Processes

, 2022
A numerically accurate, fully quantum methodology has been developed for the simulation of the dynamics and nonlinear spectroscopic signals of cavity-assisted, conical-intersection-controlled singlet fission systems.
Yang Zhao (39052), Yang Zhao, Maxim F. Gelin (3352466), Kewei Sun, Maxim F. Gelin, Kewei Sun (1628872)   +5 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source