Results 61 to 70 of about 473,238 (316)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A Route Planning and Traffic Control Model for Autonomous Intersections by Minimizing Conflict Zones
IEEE Access, 2023 Most existing studies on autonomous intersection management (AIM) primarily focus on modeling and resolving conflicts between vehicles within an intersection, assuming predetermined routes of the autonomous vehicles (AVs) as exogenous inputs ...
Yang Liu, Kejun Long, Wei Wu
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Вестник СибАДИ, 2019 Introduction. Road capacity refers to the main indicators, characterizing the working conditions of streets and highways. For the street capacity as a whole the minimum value of a certain section is taken, which includes adjustable intersections in one ...
K. Isakov +3 more
doaj +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Frontiers in OncologyN6-methyladenosine (m6A), as the most abundant RNA epitranscriptional modification in eukaryotes, its key component of the methyltransferase complex, METTL14, not only cooperates in catalyzing m6A deposition but also has functions independent of ...
Yulan Yang +3 more
doaj +1 more source
L'intertextualité dans le Roman "Nisf Majhoul" (Moitié Inconnu) de Gamal Al- Jaziri [PDF]
Maǧallaẗ Kulliyyaẗ Al-ādāb Ǧāmiʿaẗ BūrsaʿīdLa recherche des sources et l’étude des influences d’écrivain en écrivain occupent aujourdʼhui , dans les études littéraires , une place considérable .
Mohamed Elsayed Mohamed Elsawy
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Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
FoodsBackground: A diet high in purines can impair the function of the gut microbiota and disrupt purine metabolism, which is closely associated with the onset of hyperuricemia.
Jiahui Wu +8 more
doaj +1 more source