Results 31 to 40 of about 596,231 (252)

Decoding TGR5: A comprehensive review of its impact on cerebral diseases

Pharmacological Research
Currently, unraveling the enigmatic realm of drug targets for cerebral disorders poses a formidable challenge. Takeda G protein-coupled receptor 5 (TGR5), also known as G protein-coupled bile acid receptor 1, is a specific bile acid receptor.
Zehan Zhang, Yifei Zhang, Hongye Peng, Qingqian Yu, Xiangdong Kang, Ying Liu, Yuxiao Zheng, Fafeng Cheng, Xueqian Wang, Feng Li   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Optimal Allocation of the Library Space to Books Using Cuckoo Algorithm

تحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, 2015
Purpose: The goal of this research is to describe how we can arrange the books in the shelves such that leads to minimization of the movement of the clients in the library and reduction of restrictions on the number and volume of each type of book ...
houshmand moradveisi, mohammad sadi mesgari   +1 more
doaj  

Community-based multisensory environments as preventive public health interventions for mental well-being in older adults: evidence from a large-scale study in China

Frontiers in Public Health
The accelerating demographic transition has brought the mental health of older adults to the forefront of public health concerns. Middle-aged and older adults (aged 50–69 years), often described as the “young-old,” are particularly vulnerable to early ...
Han Zhang, Siqi Zhu
doaj   +1 more source

Intersectional Strategies for Targeting Amacrine and Ganglion Cell Types in the Mouse Retina

Frontiers in Neural Circuits, 2018
The mammalian retina harbors over 100 different cell types. To understand how retinal circuits work, it is essential to systematically access each type. A widely used approach for achieving targeted transgene expression exploits promoter-driven Cre lines.
Andrew Jo, Jian Xu, Sercan Deniz, Suraj Cherian, Steven H. DeVries, Steven H. DeVries, Yongling Zhu, Yongling Zhu   +7 more
doaj   +1 more source

The Spatial Different Order Derivative Method of Gravity and Magnetic Anomalies for Source Distribution Inversion

Remote Sensing, 2021
Gravity and magnetic measurements are common remote sensing strategies to obtain the property change of observed targets. Nowadays, the characteristic value of the derivatives of gravity and magnetic anomalies is commonly used to detect the source ...
Yanbo Ming, Guoqing Ma, Lili Li, Jiangtao Han, Taihan Wang   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Saturation flow versus green time at two‐stage signal controlled intersections [PDF]

Transport, 2009
Intersections are the key components of road networks considerably affecting capacity. As flow levels and experience have increased over the years, methods and means have been developed to cope with growing demand for traffic at road junctions.
Ahmed Boumediene, Kouider Brahimi, Noreddine Belguesmia, Khaled Bouakkaz   +3 more
doaj   +1 more source

Data Delivery Delay Reduction for VANETs on Bi-Directional Roadway

IEEE Access, 2016
In this paper, we investigate the data delivery delay from source to destination for VANETs on bi-directional roadways. The topology includes bi-directional roadways, left-turn lane, straight through lane, right-turn lane with traffic lights deployed at ...
Chang Guo, Demin Li, Guanglin Zhang, Zhaoyuan Cui   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source