Results 71 to 80 of about 1,636,264 (261)

The dual regulatory role of METTL14-mediated m6A modification in tumorigenesis and its underlying mechanisms

Frontiers in Oncology
N6-methyladenosine (m6A), as the most abundant RNA epitranscriptional modification in eukaryotes, its key component of the methyltransferase complex, METTL14, not only cooperates in catalyzing m6A deposition but also has functions independent of ...
Yulan Yang, Lemuge Chao, Xudong Ao, Junqing Liang   +3 more
doaj   +1 more source

Contrasting Spaces in Plautdietsch: Language Variation and Change

The Journal of Amish and Plain Anabaptist Studies, 2021
In this article, I explore linguistic variation in Plautdietsch through the lens of social variation and the resulting redistribution of linguistic forms across the community.
Roslyn Burns
doaj  

The Process of Setting the Parameters for Ensuring Passage of Oversized Cargos

The Baltic Journal of Road and Bridge Engineering, 2019
Engineering and the industry very often produce above-standard products concerning their dimensions and weights. There is often a problem with the transport of these products both within Europe and in subsequent transport all around the world. Because of
Jan Petru, Vladislav Krivda
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Characterization and Nutritional Intervention Effects of Canna edulis Type 5 Resistant Starch in Hyperlipidemia Mice

Foods
Numerous reports have indicated that the type 3 resistant starch (RS3) derived from Canna edulis can regulate lipid metabolism. However, it remains unclear whether the type 5 resistant starch (RS5) exhibits similar effects.
Houxier Li, Nan Wang, Jiahui Wu, Shuting Tan, Yan Li, Nan Zhang, Li Yang, Aji Li, Rongting Min, Maochun Xiao, Shiyao Su, Xiang Wang, Xueyong Wang   +12 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Lacticaseibacillus casei JS-2 from ‘Jiangshui’ Reduces Uric Acid and Modulates Gut Microbiota in Hyperuricemia

Foods
Lacticaseibacillus casei (JS-2) is a novel probiotic isolated from “Jiangshui”, a kind of traditional folk fermented food, which has a significant effect on hyperuricemia (HUA).
Jiahui Wu, Xiang Wang, Lvbu Aga, Leimengyuan Tang, Shuting Tan, Dachuan Zhang, Houxier Li, Li Yang, Nan Zhang, Shiyao Su, Maochun Xiao, Rongting Min, Aji Li, Xueyong Wang   +13 more
doaj   +1 more source

Modelling the Pedestrian Speed at Signalised Intersection Crosswalks for Heterogeneous Traffic Conditions

Promet (Zagreb), 2019
Pedestrian crossing speed is the key element in the design of pedestrian facilities. It depends on various attributes related to road, traffic and pedestrians.
Ankit Bansal, Tripta Goyal, Umesh Sharma   +2 more
doaj   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Lacticaseibacillus paracasei JS-3 Isolated from “Jiangshui” Ameliorates Hyperuricemia by Regulating Gut Microbiota and iTS Metabolism

Foods
Background: A diet high in purines can impair the function of the gut microbiota and disrupt purine metabolism, which is closely associated with the onset of hyperuricemia.
Jiahui Wu, Lvbu Aga, Leimengyuan Tang, Houxier Li, Nan Wang, Li Yang, Nan Zhang, Xiang Wang, Xueyong Wang   +8 more
doaj   +1 more source