Results 71 to 80 of about 3,546,741 (346)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

open access: yesMolecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella   +18 more
wiley   +1 more source

Distance Two Surjective Labelling of Paths and Interval Graphs

open access: yesDiscrete Dynamics in Nature and Society, 2021
Graph labelling problem has been broadly studied for a long period for its applications, especially in frequency assignment in (mobile) communication system, X-ray crystallography, circuit design, etc.
Sk Amanathulla   +3 more
doaj   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Interval Incidence Coloring of Subcubic Graphs

open access: yesDiscussiones Mathematicae Graph Theory, 2017
In this paper we study the problem of interval incidence coloring of subcubic graphs. In [14] the authors proved that the interval incidence 4-coloring problem is polynomially solvable and the interval incidence 5-coloring problem is NP-complete, and ...
Małafiejska Anna, Małafiejski Michał
doaj   +1 more source

A Polynomial Time Algorithm for Finding a Minimally Generalized Linear Interval Graph Pattern

open access: yesIEICE Trans. Inf. Syst., 2009
A graph is an interval graph if and only if each vertex in the graph can be associated with an interval on the real line such that any two vertices are adjacent in the graph exactly when the corresponding intervals have a nonempty intersection.
Hitoshi Yamasaki, Takayoshi Shoudai
semanticscholar   +1 more source

On intersections of interval graphs

open access: yesDiscrete Mathematics, 1980
AbstractIf one can associate with each vertex of a graph an interval of a line, so that two intervals intersect just when the corresponding vertices are joined by an edge, then one speaks of an interval graph.It is shown that any graph on v vertices is the intersection (“product”) of at most [12v] interval graphs on the same vertex set.For v=2k, k ...
openaire   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

On counting interval lengths of interval graphs

open access: yesDiscrete Applied Mathematics, 2011
AbstractGiven an interval graph G, the interval count problem is that of computing the minimum number IC(G) of interval lengths needed to represent G. Although the problem of deciding whether IC(G)=1 is equivalent to that of recognizing unit-interval graphs, which is a well-known problem having several efficient recognition approaches, very little is ...
Fabiano de S. Oliveira   +2 more
openaire   +2 more sources

Incidence matrices and interval graphs [PDF]

open access: yesPacific Journal of Mathematics, 1965
Abstract : According to present genetic theory, the fine structure of genes consists of linearly ordered elements. A mutant gene is obtained by alteration of some connected portion of this structure. By examining data obtained from suitable experiments, it can be determined whether or not the blemished portions of two mutant genes intersect or not, and
Fulkerson, D. R., Gross, O. A.
openaire   +4 more sources

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