Results 111 to 120 of about 45,415 (193)

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Stress-response exhaustion in intervertebral disc degeneration. [PDF]

Front Cell Dev Biol
Song J, Chen T, Ma L.
europepmc   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Organ-on-a-Chip Technology: Advances in Modeling Inflammation, Neurovascularization and Nociception in Human Intervertebral Disc Degeneration. [PDF]

Smart Med
Zulkiflee I, Za'aba NF, Pandit A, Mohd Isa IL.   +3 more
europepmc   +1 more source

Combination of Hypofractionated Radiation Therapy and Gilvetmab for the Treatment of Cutaneous or Subcutaneous Mast Cell Tumours in Dogs

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Gilvetmab is a caninised monoclonal antibody against canine PD‐1. Concurrent or sequential administration of anti‐PD‐1 antibodies and radiation therapy (RT) improves survival time in various species. Eighteen dogs with mast cell tumours (MCTs) were prospectively treated with 24 Gy of RT over Days 0, 7 and 21 and gilvetmab every 2 weeks ...
Tiffany W. Martin, Douglas H. Thamm, Kristen M. Weishaar   +2 more
wiley   +1 more source

Intradiscal Delivery of Notoginsenoside R1-Loaded PLGA Nanoparticles Attenuates Intervertebral Disc Degeneration in Rats. [PDF]

J Cell Mol Med
Zheng B, Zhong H, Wang Z, Qin J, Xie Z, Tang R, Hu C, Zhang X, Li J, Li S.   +9 more
europepmc   +1 more source

Elucidation of Baicalein's Anti-Intervertebral Disc Degeneration Mechanism Through Network Pharmacology and Experimental Validation. [PDF]

Cell Biochem Biophys
Wang R, Liu Z, Zhao X.
europepmc   +1 more source

Cerebrospinal Fluid Creatine Kinase as a Biomarker in Dogs With Neurologic Disease: A Multivariate Analysis to Guide Future Directions

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background Creatine kinase (CK) is typically associated with skeletal muscle injury, but elevated CK in blood or cerebrospinal fluid (CSF) may also be reflective of central nervous system damage. Previous research has therefore explored the role of CK as a biomarker of neurologic disease in veterinary patients.
Taylor A. Hanson, Michael F. Rosser, Benjamin Blair, Graeme M. Doodnaught, Chandler C. Carter, Anne M. Barger, Kari Foss   +6 more
wiley   +1 more source

Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction. [PDF]

Bioact Mater
Jiang Y, Li H, Wang W, Guo Q, Wang C, Li Y, Lu H, Chen J, Yang H, Zhao X, Zheng L, Qiao Y.   +11 more
europepmc   +1 more source

Novel dorsal occipito‐cervical fixation using a patient‐specific implant and drill guide for a complex craniocervical junction anomaly in a dog

Veterinary Surgery, EarlyView.
Abstract Objective To describe a novel dorsal occipito‐cervical fixation technique utilizing a patient‐specific implant to stabilize complex craniocervical junction anomalies (CCJAs) in a small‐breed dog. Study design Case report. Animal A 7‐month‐old male Pomeranian dog.
Tae‐Wan Kwon, Kyu‐Won Kang, Ji‐Hey Lim, Cheongwoon Cho, Byung‐Jae Kang   +4 more
wiley   +1 more source