Results 131 to 140 of about 43,436 (258)

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence

JOR SPINE, Volume 9, Issue 3, September 2026.
A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, Dmitriy Sheyn   +14 more
wiley   +1 more source

Research on the mechanism of Duhuo in treating intervertebral disc degeneration based on bioinformatics and network pharmacology. [PDF]

Medicine (Baltimore)
Yan Q, Liu F, Xu Z, Zhang C, Yang L, Wu X, Jiang C, Chen F, Li Z.   +8 more
europepmc   +1 more source

Large Language Models in Preclinical Spine Research: A Scoping Review and Expert Perspective on Evidence‐Aware Experimental Workflows

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background Preclinical spine research is limited by heterogeneous experimental reporting, fragmented documentation, and barriers to reproducibility and translational alignment. Large language models (LLMs) and related artificial intelligence (AI) technologies may support semantic interpretation, structured data extraction, and reasoning over ...
Siegmund Lang, Stefan Motov, Jonas Krueckel, Julian Scherer, Victor E. Staartjes, Karin Wuertz‐Kozak   +5 more
wiley   +1 more source

Current Perspective on Orthobiology Applications for the Treatment of Intervertebral Disc Degeneration (IDD)-A Narrative Review. [PDF]

Medicina (Kaunas)
Conza G, Trotta MC, Mastronardi C, Nocera A, Itro A, Martin G, Toro G, Lepre CC, Russo M, Toro G.   +9 more
europepmc   +1 more source

Semi‐Automated μCT‐Based Modeling of Vertebral Bony Endplate Microporosity and Mechanical Properties: Linking Microstructure to Inferred Mechanical Performance

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background The vertebral bony endplate (BEP) plays a role in regulating both mechanical load transfer and nutrient transport to the intervertebral disc, functions strongly influenced by its microstructural porosity. Variations in porosity impact bone strength, elasticity, and solute diffusion, affecting its overall mechanical competence ...
Ahmad Alminnawi, Gabriele Nasello, Katherine B. Crump, Benjamin Gantenbein, Jerome Noailly, Liesbet Geris   +5 more
wiley   +1 more source

Biomaterial-based strategies targeting ferroptosis for alleviating intervertebral disc degeneration: Advances and perspectives. [PDF]

J Orthop Translat
Fu Y, Wang Z, Wang W, Xie Y, Chen L, Tan L, Liu M.   +6 more
europepmc   +1 more source

Transgenic Conversion of Omega‐6 to Omega‐3 Fatty Acids via fat‐1 Reduces Obesity‐Related Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 3, September 2026.
We investigated whether transgenic conversion of omega‐6 to omega‐3 fatty acids mitigates obesity‐associated intervertebral disc (IVD) degeneration. Using fat‐1 mice on a high‐fat diet, we observed that endogenous omega‐3 production prevented diet‐induced disc pathology, metabolic dysfunction, and reduced systemic inflammation, indicating a protective ...
Shirley N. Tang, Kristin L. Lenz, Emma Shen, Collin Murray, Nikitha Ada, Sarada Prasad, Mohammed Kuziez, Farshid Guilak, Arin K. Oestreich   +8 more
wiley   +1 more source

Intervertebral Disc Elastography to Relate Shear Modulus and Relaxometry in Compression and Bending. [PDF]

Bioengineering (Basel)
Davis ZR, Gossett PC, Wilson RL, Kim W, Mei Y, Butz KD, Emery NC, Nauman EA, Avril S, Neu CP, Chan DD.   +10 more
europepmc   +1 more source

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source

Hybrid membrane nanovesicles reprogram macrophages to resolve oxidative stress in intervertebral disc degeneration. [PDF]

Mater Today Bio
Huang Y, Su M, Li M, Ma Q, Wang X, Chen Z, Chen Y, Xu B, Chen R, Lu Z, Lan Z.   +10 more
europepmc   +1 more source