Results 121 to 130 of about 43,248 (263)

Antioxidant biomaterials in intervertebral disc regeneration: current status and future clinical translation. [PDF]

Front Bioeng Biotechnol
Zhang Z, Hua R, Wang Y, Wang J, Li X, Zhou F, Mi J, Chu L, Jiang C, Che Y, Han F, Chu G.   +11 more
europepmc   +1 more source

Hyper‐buoyancy flotation increases cervical disc height and reduces vertebral stiffness, with only partial reversal after acute 1 g axial loading

Experimental Physiology, EarlyView.
Abstract Exposure to microgravity is associated with stature increases, moderate‐to‐severe back/neck pain and elevated lumbar and cervical intervertebral disc (IVD) herniation risk post‐flight. Whilst lumbar pathophysiology has been investigated, little attention has been placed on the cervical spine.
D. Marcos‐Lorenzo, P. Hernández Bernal, R. Fernández Corujo, A. Gil Martínez, J. Swanenburg, D. A. Green   +5 more
wiley   +1 more source

Metabolic reprogramming in intervertebral disc degeneration: mechanisms and therapeutic opportunities. [PDF]

Front Cell Dev Biol
Lu Q, He C.
europepmc   +1 more source

Effects of tumour necrosis factor and interleukin‐6 inhibitor therapy on exercise‐related visceral adipose tissue reduction in rheumatoid arthritis

Experimental Physiology, EarlyView.
Abstract Excess visceral adipose tissue (VAT) mass increases cardiovascular disease risk. Exercise supports overall health and VAT mass reduction in rheumatoid arthritis (RA). Unlike tumour necrosis factor (TNF), interleukin‐6 (IL‐6) is upregulated following exercise and is involved in free fatty acid mobilisation and might mediate the reduction in VAT
Simon Jønck, Malte Lund Adamsen, Iben E. Rasmussen, Anna A. Lytzen, Mathilde Løk, Morten Asp Vonsild Lund, Benjamin Nerup, Lene Wohlfahrt Dreyer, Peter G. Jørgensen, Niels Vejlstrup, Lars Køber, Søren Jacobsen, Bente Klarlund Pedersen, Helga Ellingsgaard, Pil Højgaard, Ronan M. G. Berg, Regitse Højgaard Christensen   +16 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Epigenetic research methods and animal models for intervertebral disc degeneration (Review). [PDF]

Mol Med Rep
Cui X, Zeng L, Zhang W, Xi L, Wang R, Jia D, Safa, Feng H, Jia H.   +8 more
europepmc   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Intervertebral disc progenitor cells: roles in regeneration and disease. [PDF]

Stem Cell Res Ther
Yan P, He J, Huang Y, Lin C, Huang S, Hu O, Lin P, Wang Y, Jin H, Li Y, Qin Q, Wu Y, Wu J, Pu J, Xie Y, Chen L, Lin S, Gan Y, Liu P.   +18 more
europepmc   +1 more source

What Is Your Diagnosis? Leukocytosis With Abnormal WDF and WNR Scattergrams From the Sysmex XN‐1000V in a Dog

Veterinary Clinical Pathology, EarlyView.
Javier Martínez‐Caro, Marta Lemos, Josep Pastor   +2 more
wiley   +1 more source

TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain‐like behaviors in rats with neuropathic pain

The Journal of Physiology, EarlyView.
Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez, Kimberly Gomez, Alessandro Porro, Gerhard Thiel, Anna Moroni, Heather N. Allen, Rajesh Khanna, Andrea Saponaro   +7 more
wiley   +1 more source