Results 51 to 60 of about 52,505 (294)

Effect of Pb exposure on the cells and matrix of the intervertebral disc of rats

Regulatory Mechanisms in Biosystems, 2017
Degenerative spine diseases are common throughout the world. There are many factors that lead to these diseases. One of these exogenous factors may be Pb exposure.
V. Maltseva
doaj   +1 more source

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source

TWEAK and TSLP in disc degeneration and spontaneous hernia resorption

JOR Spine, 2020
Spontaneous degeneration of an intervertebral disc is caused by inflammation that accompanies exposure of the avascular nucleus pulposus to circulation, triggering an autoimmune inflammatory reaction.
Tetsuro Ohba, Hirotaka Haro
doaj   +1 more source

Morphometric Study of Lumbar Intervertebral Spaces (discs) by Using MRI.

Journal of Lumbini Medical College, 2020
Introduction: The radiological space between two vertebrae is known as intervertebral space (height) which corresponds to the thickness of the intervertebral disc.
Dil Islam Mansur, Pragya Shrestha, Sunima Maskey, Kalpana Sharma, Subindra Karki, Trishna Kisiju   +5 more
doaj   +1 more source

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

Investigation of the Role of Osteoporotic Vertebra Degeneration on the Stability of the Lumbar Spine: In Silico Modelling under Compressive Loading

Bioengineering
An evaluation of the impact of osteoporosis on loss of spinal stability, with or without intervertebral disc degeneration, using computational analysis is presented.
Olga Chabarova, Jelena Selivonec, Alicia Menendez Hurtado   +2 more
doaj   +1 more source

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

Advanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong, Wenxiao Shi, Xingzhu Liu, Hang Yu, Yinghui Wu, Yanzhang Xia, Caichun Yue, Chongkai Yang, Cong Shen, Renjun Pei, Tianwen Xin, Hailong Pei, Jun Shen   +12 more
wiley   +1 more source

Spatial and Diurnal Variations in Sodium Content Within Intervertebral Disc Tissue. [PDF]

JOR Spine
Cycles of daily movement and nighttime relaxation create cycles in fixed charge density and tissue osmolarity in vivo. Previous measurements of these parameters have been limited by spatial resolution and an inability to measure in situ. This study develops and validates a novel application of laser ablation‐inductively coupled plasma‐mass spectrometry
Marshall JT, Lutton AD, Grinstaff MW, Olesik JW, Walter BA.   +4 more
europepmc   +2 more sources

Human iPSCs Derived MSCs‐Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Senescent nucleus pulposus cells drive inflammatory M1 macrophage polarization, exacerbating intervertebral disc degeneration (IDD). Conversely, M1 macrophages accelerate NP cell senescence, creating a vicious cycle. iPSCs‐derived mesenchymal stem cell (iMSCs) exosomes break this loop by delivering miR‐100‐5p to suppress mTORC1/glycolysis in ...
Qian Xiang, Jiawen Zhan, Shuo Tian, Yongzhao Zhao, Zhenquan Wu, Jialiang Lin, Longting Chen, Longjie Wang, Shuai Jiang, Zhuoran Sun, Weishi Li   +10 more
wiley   +1 more source

A novel rat model of lumbar disc herniation induced by puncture: accurate positioning and controllable degree of herniation

Journal of Orthopaedic Surgery and Research
Background Lumbar disc herniation (LDH) is the serious stage of intervertebral disc degeneration (IDD), and the location and degree of intervertebral disc herniation are closely related to clinical symptoms and signs.
Ming Yang, Jiangling Zhou, Qiandong Yang, Bo Yu, Juan Cai, Tianyong Hou   +5 more
doaj   +1 more source