Results 1 to 10 of about 20,231 (187)
Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats [PDF]
Frontiers in Pharmacology, 2023 Apoptosis and extracellular matrix degradation of the nucleus pulposus are the main initiators of intervertebral disc degeneration (IVDD) and can be explained by endoplasmic reticulum (ER) stress.
Yan Chen +10 more
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Degeneration of the intervertebral disc. [PDF]
Arthritis research & therapy, 2003 The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body.
Jill Urban, Sally Roberts
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Notochord Cells in Intervertebral Disc Development and Degeneration [PDF]
Journal of Developmental Biology, 2016 The intervertebral disc is a complex structure responsible for flexibility, multi-axial motion, and load transmission throughout the spine. Importantly, degeneration of the intervertebral disc is thought to be an initiating factor for back pain. Due to a
Matthew R. McCann, Cheryle A. Séguin
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Molecular Mechanisms of Intervertebral Disc Degeneration
Spine Surgery and Related Research, 2019 Intervertebral disc degeneration is a well-known cause of disability, the result of which includes neck and back pain with associated mobility limitations.
Sean Rider, Shuichi Mizuno, James Kang
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Experimental intervertebral disc degeneration models [PDF]
, 2023 Intervertebral disc degeneration is a major health problem of close concern to both young and old. The problem is also growing as the global population ages.
İkinci̇ Keleş, Ayşe +1 more
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Treatment of Intervertebral Disc Degeneration
Orthopaedic Surgery, 2022 Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs. IDD results from many factors, including genetic factors, aging, mechanical injury, malnutrition, and so on.
Jingguo Xin +5 more
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The role of ageing and oxidative stress in intervertebral disc degeneration
Frontiers in Molecular Biosciences, 2022 Intervertebral disc degeneration (IDD) is the primary cause of intervertebral disc (IVD) disease. With the increased ageing of society, an increasing number of patients are plagued by intervertebral disc disease. Ageing not only accelerates the decreased
Pengfei Wen +5 more
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Application study of 3D LAVA-Flex on lumbar intervertebral disc degeneration
European Journal of Medical Research, 2021 Background Degeneration of the intervertebral discs are very common diseases, indicating the specific or malignant changes in intervertebral disc component, structure and function.
Tiefang Liu +6 more
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Genetic Therapy for Intervertebral Disc Degeneration [PDF]
International Journal of Molecular Sciences, 2021 Intervertebral disc (IVD) degeneration can cause chronic lower back pain (LBP), leading to disability. Despite significant advances in the treatment of discogenic LBP, the limitations of current treatments have sparked interest in biological approaches, including growth factor and stem cell injection, as new treatment options for patients with chronic ...
Eun Roh +7 more
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Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration
Journal of Orthopaedic Surgery and Research, 2021 Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
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