Results 1 to 10 of about 82,752 (303)

The role of ageing and oxidative stress in intervertebral disc degeneration

Frontiers in Molecular Biosciences, 2022
Intervertebral disc degeneration (IDD) is the primary cause of intervertebral disc (IVD) disease. With the increased ageing of society, an increasing number of patients are plagued by intervertebral disc disease. Ageing not only accelerates the decreased
Pengfei Wen, Bolong Zheng, Binfei Zhang, Tao Ma, Linjie Hao, Yumin Zhang   +5 more
doaj   +2 more sources

Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions

Bone Research, 2021
Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder that results in major social and economic burdens. Recent research has identified inflammation and related signaling pathways as important factors in the onset ...
Feng-Juan Lyu, Haowen Cui, Xu Cao
exaly   +2 more sources

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

Nature Communications, 2021
Intervertebral disc degeneration is highly prevalent within the elderly population and is a leading cause of chronic back pain and disability. Due to the link between disc degeneration and senescence, we explored the ability of the Dasatinib and ...
Shira N Johnston, Garrett A Sessions, Brian O Diekman   +2 more
exaly   +2 more sources

Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration

Frontiers in Pharmacology, 2022
Low back pain has been found as a major cause of global disease burden and disability. Intervertebral disc degeneration is recognized as the vital factor causing low back pain.
Zhichao Li, Yan Wu, Guoqing Tan, Zhanwang Xu, Haipeng Xue, Haipeng Xue   +5 more
doaj   +2 more sources

Mn-MIL-100@AKG alleviates intervertebral disc degeneration by regulating mitophagy [PDF]

Materials Today Bio
Currently, the therapy of intervertebral disc degeneration (IDD) mostly focuses on basic molecular causes. Research on the alterations of metabolites in the intervertebral disc prior to and following intervertebral disc degeneration (IDD) remains ...
Xianglong Chen, Haiyang Gao, Anran Zhang, Pengzhi Shi, Yuhang Chen, Zhangrong Cheng, Wang Wu, Wenbo Wu, Yukun Zhang   +8 more
doaj   +2 more sources

Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Nature Communications
Intervertebral disc degeneration is a natural process during aging and a leading cause of lower back pain. Here, we generate a comprehensive atlas of nucleus pulposus cells using single-cell RNA-seq analysis of human nucleus pulposus tissues (three males
Fan Chen, Linchuan Lei, Shunlun Chen, Zhuoyang Zhao, Yuming Huang, Guowei Jiang, Xingyu Guo, Zemin Li, Zhaomin Zheng, Jianru Wang   +9 more
doaj   +2 more sources

Role of macrophage in intervertebral disc degeneration [PDF]

Bone Research
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang   +6 more
doaj   +2 more sources

Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats

Frontiers in Pharmacology, 2023
Apoptosis and extracellular matrix degradation of the nucleus pulposus are the main initiators of intervertebral disc degeneration (IVDD) and can be explained by endoplasmic reticulum (ER) stress.
Yan Chen, Yan Chen, Baixing Li, Baixing Li, Yue Xu, Tangjun Zhou, Tangjun Zhou, Changqing Zhao, Changqing Zhao, Jie Zhao, Jie Zhao   +10 more
doaj   +1 more source

Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment

Cell Proliferation, 2023
Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also imposes a severe economic burden on patients and society. Among symptomatic LBP, approximately 40% is caused by intervertebral disc degeneration (IDD). IDD is the
Yidian Wang, Huiguang Cheng, Tao Wang, Kun Zhang, Yumin Zhang, Xin Kang   +5 more
semanticscholar   +1 more source

Intervertebral disc degeneration—Current therapeutic options and challenges

Frontiers in Public Health, 2023
Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's declining function and the development of pain, it may affect one's physical health, mental health, and socioeconomic status.
Ankit Samanta, T. Lufkin, P. Kraus
semanticscholar   +1 more source