Results 51 to 60 of about 37,526 (187)

Frequency of Disc Degeneration at Different Levels of Cervical Vertebrae in Adult Patients with Neck Pain on Magnetic Resonance Imaging [PDF]

, 2020
Background:Disc degeneration is terminology used for heterogeneous changes affecting the anatomy and physiology of the intervertebral disc. Disc degeneration alters the material properties of the intervertebral disc leading to an unfavorable distribution
., Khansa, Arouj, Saba, Farooq, S. Muhammad Yousaf, Hafeez, Hasham, Haider, Jamal, Rafiq, Rana Iqra, Ramzan, Khawar, Ul Hassan, S Noor   +7 more
core   +1 more source

RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE? [PDF]

, 2016
Transcription factor tonicity-responsive enhancer-binding protein (TonEBP/NFAT5) is critical for osmo-adaptation and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche.
Johnson, Zariel I., Risbud, Makarand V., Shapiro, Irving M.   +2 more
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In Vivo Mouse Intervertebral Disc Degeneration Model Based on a New Histological Classification. [PDF]

PLoS ONE, 2016
Although human intervertebral disc degeneration can lead to several spinal diseases, its pathogenesis remains unclear. This study aimed to create a new histological classification applicable to an in vivo mouse intervertebral disc degeneration model ...
Takashi Ohnishi, Hideki Sudo, Koji Iwasaki, Takeru Tsujimoto, Yoichi M Ito, Norimasa Iwasaki   +5 more
doaj   +1 more source

Correlation of Early Outcomes and Intradiscal Interleukin-6 Expression in Lumbar Fusion Patients. [PDF]

, 2020
OBJECTIVE: To determine if there is correlation between intradiscal levels of interleukin-6 (IL-6) and early outcome measures in patients undergoing lumbar fusion for painful disc degeneration.
Anderson, D Greg, Antonacci, Christopher L, Kepler, Chris K, Koerner, John D, Markova, Dessislava Z, Mendelis, Joseph, Schroeder, Greg D, Vaccaro, Alexander R   +7 more
core   +1 more source

VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process

BMC Research Notes, 2018
Objective During degeneration of the intervertebral disc ingrowth of blood vessels and nerves into the disc are associated with back pain. Vascular endothelial growth factors promote vasculogenesis by binding to the membrane vascular endothelial growth ...
Simona Capossela, Alessandro Bertolo, Kapila Gunasekera, Tobias Pötzel, Martin Baur, Jivko V. Stoyanov   +5 more
doaj   +1 more source

BIOCHEMICAL AND BIOMECHANICAL SUBSTANTIATION OF REPARATIVE REGENERATION OF INTERVERTEBRAL DISCS IN PATIENTS WITH DEGENERATIVE DISC DISEASES

Східноукраїнський медичний журнал, 2020
Degenerative disc diseases occupy the second place in the overall structure of morbidity with temporary disability. In 40% of patients with spinal osteochondrosis, diseases of the locomotor apparatus and connective tissue cause primary disability.
J. A. Bodnarchuk, M. V. Khyzhnjak, О. О. Potapov, N. G. Chopik   +3 more
doaj  

MRI of the axial skeleton in spondyloarthritis : the many faces of new bone formation [PDF]

, 2019
Spondyloarthritis has two hallmark features: active inflammation and structural lesions with new bone formation. MRI is well suited to assess active inflammation, but there is increasing interest in the role of structural lesions at MRI.
Carron, Philippe, Elewaut, Dirk, Herregods, Nele, Jans, Lennart, Jaremko, Jacob L, Laloo, Frederiek, Van den Bosch, Filip, Verstraete, Koenraad   +7 more
core   +1 more source

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis

Journal of Pharmacological Sciences, 2018
Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun, Yuekui Jian, Hongying Fu, Bo Li   +3 more
doaj  

Advances in Comparative Medical Research on Anatomy and Histological Structure of Intervertebral Discs in Humans and Other Animals

Shiyan dongwu yu bijiao yixue
The 2023 China Health Report on Spine Degeneration noted a significant increase in lumbar surgery among patients under 35 years old in recent years, indicating a trend towards younger onset of cervical and lumbar diseases.
ZHANG Li, HAN Lingxia, KUANG Yu
doaj   +1 more source

キカイテキソンショウノテイドノチガイガカルボニルストレスハツゲンニオヨボスエイキョウ [PDF]

, 2017
　 Low back pain is a significant public health problem worldwide. Intervertebral disc degeneration is most significant known risk factor for low back pain. Yet the mechanisms of degeneration remain relatively unknown.
サイモン タング, 日比野 至
core   +1 more source