Results 51 to 60 of about 84,616 (318)

A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration-Correlation with histological grading in a rabbit disc degeneration model. [PDF]

, 2019
Introduction:Estimation of intervertebral disc degeneration on magnetic resonance imaging (MRI) is challenging. Qualitative schemes used in clinical practice correlate poorly with pain and quantitative techniques have not entered widespread clinical use.
Chamoli, Uphar, Diwan, Ashish D, Kato, Kenji, Masuda, Koichi, Miyazaki, Shingo, Sheldrick, Kyle   +5 more
core   +1 more source

Mitochondrial Dysfunction in Oxidative Stress‐Mediated Intervertebral Disc Degeneration

Orthopaedic Surgery, 2022
Intervertebral disc degeneration (IVDD) is the most common contributor to low back pain (LBP). Recent studies have found that oxidative stress and reactive oxygen species (ROS) play an important role in IVDD.
Dian-Kai Wang, Huo-Liang Zheng, Wenqi Zhou, Zheng-Wei Duan, Shengdan Jiang, Bo Li, Xinfeng Zheng, Lei-Sheng Jiang   +7 more
semanticscholar   +1 more source

Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy

SAGE Open Medicine, 2018
Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity.
Joseph Fernandez-Moure, Caitlyn A Moore, Keemberly Kim, Azim Karim, Kevin Smith, Zonia Barbosa, Jeffrey Van Eps, Pranela Rameshwar, Bradley Weiner   +8 more
doaj   +1 more source

Gut-disc axis: A cause of intervertebral disc degeneration and low back pain?

European spine journal, 2022
Low back pain (LBP), a widely prevalent and costly disease around the world, is mainly caused by intervertebral disc (IVD) degeneration (IDD). Although numerous factors may trigger this degenerative process, microbiome dysbiosis has recently been ...
Wentian Li, Kaitao Lai, N. Chopra, Zhaomin Zheng, Abhirup Das, A. Diwan   +5 more
semanticscholar   +1 more source

Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K/AKT/NF-κB pathway and regulating NLRP3 inflammasome-mediated pyroptosis

InflammoPharmacology, 2022
Objectives As one of the major causes of low back pain, intervertebral disc degeneration (IDD) has caused a huge problem for humans. Increasing evidence indicates that NLRP3 inflammasome-mediated pyroptosis of NP cells displays an important role in the ...
Yuhang Gong, Jianxin Qiu, Ting Jiang, Ze Li, Weikang Zhang, Xiao-yuan Zheng, Zixuan He, Wei-Fiu Chen, Zhangfu Wang, Xingbing Feng, Meizhen Wang, Zhenghua Hong   +11 more
semanticscholar   +1 more source

Application of stem cells in the repair of intervertebral disc degeneration

Stem cell research & therapeutics, 2022
Intervertebral disc degeneration (IDD) is a common disease that increases with age, and its occurrence is stressful both psychologically and financially. Stem cell therapy for IDD is emerging. For this therapy, stem cells from different sources have been
Wentao Zhang, Tianze Sun, Ying Li, Ming Yang, Yantao Zhao, Jing Liu, Zhonghai Li   +6 more
semanticscholar   +1 more source

Development and degeneration of the intervertebral discs

Molecular Medicine Today, 1995
The intervertebral discs undergo profound changes in structure and composition during development and aging. They also degenerate much earlier than other cartilaginous tissues, and in severe cases may lose function completely. The reasons for this early degeneration are unknown, but external factors, such as mechanical overload on the spine, or smoking,
Urban, J, Roberts, S
openaire   +2 more sources

Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc Degeneration

International Journal of Molecular Sciences, 2022
In this study, we used single-cell transcriptomic analysis to identify new specific biomarkers for nucleus pulposus (NP) and inner annulus fibrosis (iAF) cells, and to define cell populations within non-degenerating (nD) and degenerating (D) human ...
Hosni Cherif, M. Mannarino, Alain S Pacis, J. Ragoussis, O. Rabau, J. Ouellet, L. Haglund   +6 more
semanticscholar   +1 more source

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis

Journal of Pharmacological Sciences, 2018
Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun, Yuekui Jian, Hongying Fu, Bo Li   +3 more
doaj   +1 more source

Outcome of anterior lumbar interbody fusion : a retrospective study of clinical and radiologic parameters [PDF]

, 2017
Objective. This study aims to critically evaluate the long-term results of stand-alone anterior lumbar interbody fusion (ALIF), without use of rhBMP-2, as a therapeutic option for symptomatic patients with degenerative disc disease (DDD).
Caemaert, Jacques, COUVREUR, TIM, Everaert, Karel, Hallaert, Giorgio, HERREGODTS, PATRICK, Kalala Okito, Jean-Pierre, Pinson, Harry, Van Roost, Dirk   +7 more
core   +2 more sources