Results 51 to 60 of about 82,752 (303)

An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration

JOR Spine, 2022
Intervertebral disc degeneration (IVDD) is the pathological basis of disc herniation, spinal stenosis, and other related diseases, and the lower back pain it produces lays a heavy financial burden on individuals and society.
Chao Song, Weiye Cai, Fei Liu, K. Cheng, Daru Guo, Zongchao Liu   +5 more
semanticscholar   +1 more source

Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy

Cells, 2022
Intervertebral disc degeneration (IVDD) is a common pathological condition responsible for lower back pain, which can significantly increase economic and social burdens.
Jiaxing Chen, Xinyu Yang, Yi Feng, Qiaochu Li, Jingjin Ma, Linbang Wang, Zhengxue Quan   +6 more
semanticscholar   +1 more source

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis

Journal of Pharmacological Sciences, 2018
Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun, Yuekui Jian, Hongying Fu, Bo Li   +3 more
doaj   +1 more source

Outcome of anterior lumbar interbody fusion : a retrospective study of clinical and radiologic parameters [PDF]

, 2017
Objective. This study aims to critically evaluate the long-term results of stand-alone anterior lumbar interbody fusion (ALIF), without use of rhBMP-2, as a therapeutic option for symptomatic patients with degenerative disc disease (DDD).
Caemaert, Jacques, COUVREUR, TIM, Everaert, Karel, Hallaert, Giorgio, HERREGODTS, PATRICK, Kalala Okito, Jean-Pierre, Pinson, Harry, Van Roost, Dirk   +7 more
core   +2 more sources

Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration

Journal of Nanobiotechnology, 2021
Exosome therapy is a promising therapeutic approach for intervertebral disc degeneration (IVDD) and achieves its therapeutic effects by regulating metabolic disorders, the microenvironment and cell homeostasis with the sustained release of microRNAs ...
Hong-Yuan Xing, Zengjie Zhang, Qijiang Mao, Chenggui Wang, Youlong Zhou, Xiaopeng Zhou, Liwei Ying, Haibin Xu, Shaojun Hu, Ning Zhang   +9 more
semanticscholar   +1 more source

Allogeneic fibroblasts ameliorate intervertebral disc degeneration by reducing osteophytes in rabbits

Frontiers in Medicine
IntroductionLow back pain (LBP) was commonly induced by intervertebral disc degeneration (IVDD), which is accompanied by the loss of disc height and osteophyte generation.
Chen Chen, Yizhuo Huang, Lei Shi, Li Zhou, Shenao Zhou, Shenao Zhou, Hongjin Wan, Xiao Yang, Jie Zhao   +8 more
doaj   +1 more source

FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs. [PDF]

, 2017
Chondrodystrophy in dogs is defined by dysplastic, shortened long bones and premature degeneration and calcification of intervertebral discs. Independent genome-wide association analyses for skeletal dysplasia (short limbs) within a single breed ...
Aguilar, Miriam, Bannasch, Danika L, Brown, C Titus, Brown, Emily A, Dickinson, Peter J, Ettinger, Cassandra L, Korff, Courtney, Lind, Jenna, Mansour, Tamer, Pollard, Rachel, Raudsepp, Terje, Sturges, Beverly K, Varon, Samuel, Young, Amy E   +13 more
core   +2 more sources

Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions

Theranostics, 2021
Low back pain (LBP) is a major reason for disability, and symptomatic intervertebral disc (IVD) degeneration (IDD) contributes to roughly 40% of all LBP cases.
A. Kamali, R. Ziadlou, G. Lang, Judith Pfannkuche, S. Cui, Zhen Li, R. G. Richards, M. Alini, S. Grad   +8 more
semanticscholar   +1 more source

Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs after Thoracolumbar Intervertebral Disk Herniation [PDF]

, 2017
Background: Ascending/descending myelomalacia (ADMM) is a severe complication of thoracolumbar intervertebral disk herniation (TL-IVDH) in dogs. Hypothesis/Objectives: To investigate the prevalence and risk factors for ADMM in nonambulatory dogs with ...
Aikawa, Amsellem, Bergknut, Bezuidenhout, Boekhoff, Ferreira, Fingeroth, Griffiths, Henke, Henke, Ito, Jeffery, Jeffery, Kato, Kranenburg, Lahunta, Laitinen, Levine, Lu, Marquis, Mayer, Muguet-Chanoit, Okada, Okada, Olby, Olby, Pais, Penning, Platt, Priester, Sato, Scott, Shinzato, Smolders, Zachary   +34 more
core   +1 more source

Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration

Cells, 2021
Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic and catabolic processes in the intervertebral disc, leading to an alteration in the composition of the extracellular matrix (ECM), loss of nucleus pulposus (NP ...
Zoe Krut, G. Pelled, D. Gazit, Z. Gazit
semanticscholar   +1 more source