Results 51 to 60 of about 5,630,201 (172)

Revisiting intervertebral disc degeneration: lipid metabolism disorders as overlooked contributors to complex pathology

Frontiers in Immunology
With the global population aging, intervertebral disc degeneration (IDD), an aging-related disease, has been confirmed to be an important cause of low back pain (LBP).
Shuang Chen, Shuang Chen, Hongshan Liu, Kaizhong Wang, Kaizhong Wang, Hui Wang, Hui Wang, Anqiao Xu, Moran Suo, Moran Suo, Xin Chen, Xin Chen, Zhonghai Li, Zhonghai Li   +13 more
doaj   +1 more source

HISTOLOGICAL MARKERS OF DEGENERATION AND REGENERATION OF THE HUMAN INTERVERTEBRAL DISK

Coluna/Columna
Objective: To define histological scores for intervertebral disc degeneration that would enable the definition of morphological characteristics of disease, besides improving knowledge of the lumbar degenerative disc disease by means of ...
MANUELA PELETTI-FIGUEIRÓ, ISRAEL SILVEIRA DE AGUIAR, SUELEN PAESI, DENISE CANTARELLI MACHADO, SERGIO ECHEVERRIGARAY, MARIANA ROESCH-ELY, ASDRUBAL FALAVIGNA, JOÃO ANTONIO PÊGAS HENRIQUES   +7 more
doaj   +1 more source

Overactivation of NF-kB pathway can induce apoptosis by down-regulating glycolysis in human degenerative nucleus pulposus cells

Heliyon
Intervertebral disc herniation, a prevalent condition in spinal surgery that frequently results in low back pain and lower limb dysfunction, significantly impacting patients' quality of life.
Pan Tang, Bo Liu
doaj   +1 more source

DIGITAL PROCESSING FOR FLUOROSCOPY-BASED INTERVERTEBRAL KINEMATIC ANALYSIS [PDF]

, 2011
Spinal degenerations can lead to segmental instability that is regarded as a major cause of back pain and is often an important factor in deciding on surgical fusion or prosthesis implant.
Cerciello, Tommaso
core   +1 more source

Congenital block vertebrae and intervertebral disc protrusion in a young cat

Journal of Feline Medicine and Surgery Open Reports, 2019
Case summary A 6-month-old domestic shorthair cat was evaluated for proprioceptive ataxia of the pelvic limbs. Over 2 months, the cat became poorly ambulatory, paraparetic with proprioceptive ataxia and developed a firm, distended bladder with ...
Yvette C Crowe, Georgina Child, Richard Lam, Ross McGregor   +3 more
doaj   +1 more source

Machine learning and single-cell analysis identify the mitophagy-associated gene TOMM22 as a potential diagnostic biomarker for intervertebral disc degeneration

Heliyon
Background: Mitophagy selectively eliminates potentially cytotoxic and damaged mitochondria and effectively prevents excessive cytotoxicity from damaged mitochondria, thereby attenuating inflammatory and oxidative responses.
Yinghao Wu, Shengting Wu, Zhiheng Chen, Erzhu Yang, Haiyue Yu, Guowang Zhang, XiaoFeng Lian, JianGuang Xu   +7 more
doaj   +1 more source

Intervertebral disc degeneration and possibilities of tissue engineering

Хирургия позвоночника, 2017
Objective – to study the role of different structures of the intervertebral disc in its degeneration, as well as the possibilities of tissue engineering in the treatment of this disease.
Vadim A. Byvaltsev, Ivan A. Stepanov, Lyudmila A. Bardonova, Evgeniy G. Belykh   +3 more
doaj   +1 more source

Hansen type II disc disease in dogs: pathophysiology, clinicalsurgical approach and controversies

Semina: Ciências Agrárias, 2014
Protrusion of the intervertebral disc can cause chronic progressive compression of the spinal cord, and the neurological associated signs vary according to anatomical location, duration and dynamic force of compression.
Paulo Vinicius Tertuliano Marinho, Mônica Vicky Bahr Arias , Carolina Camargo Zani, Bruno Watanabe Minto   +3 more
doaj   +1 more source

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment

Journal of Orthopaedic Translation
As a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory ...
Yang Liu, Yiming Dou, Xun Sun, Qiang Yang   +3 more
doaj   +1 more source

Sensory nerve ingrowth, cytokines, and instability of discogenic low back pain: A review

Spine Surgery and Related Research, 2018
Introduction: Many patients suffer from discogenic low back pain. However, the mechanisms, diagnosistic strategy, and treatment of discogenic low back pain all remain controversial.
Seiji Ohtori, Masayuki Miyagi, Gen Inoue
doaj   +1 more source