Results 111 to 120 of about 13,902 (256)

MRI Evaluation of Lumbar Disc Degenerative Disease [PDF]

, 2015
Introduction: Lower back pain secondary to degenerative disc disease is a condition that affects young to middle-aged persons with peak incidence at approximately 40 y.
Mehta, Chetan, Patel, Narrotam, Patel, Rupal, Suthar, Pokhraj   +3 more
core   +2 more sources

Clarifying the nomenclature of intervertebral disc degeneration and displacement: from bench to bedside.

International journal of clinical and experimental pathology, 2015
As a significant determinant of low back pain, intervertebral disc degeneration (IDD) has attracted more and more attention of both investigators and physicians. Disc herniation, termed as intervertebral disc displacement, is amongst the most prevalent spinal diseases closely linked with IDD.
Hai-Qiang, Wang, Dino, Samartzis
openaire   +1 more source

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Comparação dos métodos de Farfan modificado e de Frobin, para aferição da altura do disco intervertebral [PDF]

, 2014
OBJECTIVE: To evaluate the reliability and reproducibility of Farfan modified and Frobin methods to measure the intervertebral disc height in radiographs with inter- and intraobserver comparison.
Del Curto, David, Kanas, Michel, Leite, Marcio Squassoni, Martins, Délio Eulálio, Puertas, Eduardo Barros, Ueta, Renato Hiroshi Salvioni, Wajchenberg, Marcelo   +6 more
core   +3 more sources

New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics

Rare Metals, EarlyView.
ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu, Shao‐Sheng Jia, Rong‐Bang Sun, Tong Zhang, Ling‐Chuang Bai, Di Mei, Shi‐Jie Zhu, Lan Chen, Shao‐Kang Guan   +8 more
wiley   +1 more source

Emerging Triboelectric Nanogenerators for In‐Body Implantation

Small Methods, EarlyView.
This review explores functional implantable triboelectric nanogenerators in biomedical applications, discussing their mechanisms, electricity generation, and design approaches. To solve postimplantation challenges, four types of triboelectric nanogenerators (TENGs) are introduced: stretchable, bioadhesive, on‐demand biodegradable, and multiresponsive ...
Xiao Xiao, Xiangchun Meng, Yong Hyun Kwon, Yoojin Park, Sang‐Woo Kim   +4 more
wiley   +1 more source

Refined Phenotyping of Modic Changes: Imaging biomarkers of prolonged severe low back pain and disability [PDF]

, 2016
Imaging biomarkers of prolonged severe low back pain and ...
Bow, HYC, Cheung, KMC, Karppinen, J, Luk, KDK, Määttä, JH, Paananen, M, Samartzis, D   +6 more
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Long-term creep behavior of the intervertebral disk: comparison between bioreactor data and numerical results [PDF]

, 2014
The loaded disk culture system is an intervertebral disk (IVD)-oriented bioreactor developed by the VU Medical Center (VUmc, Amsterdam, The Netherlands), which has the capacity of maintaining up to 12 IVDs in culture, for approximately 3 weeks after ...
Alves, J. L., Castro, André, Claro, José Carlos Pimenta, Detiger, S. E. L., Mullender, M. G., Paul, C. P. L., Royen, B. J. van, Smit, T. H.   +7 more
core   +2 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source